MilliporeSigma

VDR

vitamin D (1,25- dihydroxyvitamin D3) receptor

Synonyms:
NR1I1
Species:
UniProtKB ID:
Gene ID:
  • Human(7421) Summary: This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]
  • Mouse(22337) vitamin D receptor
  • Rat(24873) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • naked mole-rat(101710294) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • domestic guinea pig(100734655) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • sheep(101107273) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • sheep(100294603) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • cow(533656) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • Horse(100034072) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • domestic cat(100316614) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • dog(486588) vitamin D (1,25- dihydroxyvitamin D3) receptor
  • chicken(395988) vitamin D (1,25- dihydroxyvitamin D3) receptor

Custom & Knockdown Gene Products

  • siRNA

    Shop predesigned siRNA that are designed using the proprietary Rosetta Inpharmatics algorithm.

  • shRNA

    Shop the largest, most validated shRNA collection and build your own clone sets.

  • Custom Gene Products

    We offer a comprehensive portfolio of DNA oligos, RNA oligos and predesigned primers.

Small Molecule - Agonist

Product Number
Description
Species
25-Hydroxycholecalciferol, ≥98% (HPLC),
Species
human
Cholecalciferol, meets USP testing specifications,
Species
human
Cholecalciferol, ≥98% (HPLC),
Species
human
Calcitriol, European Pharmacopoeia (EP) Reference Standard,
Species
human
Alfacalcidol, European Pharmacopoeia (EP) Reference Standard,
Species
human

Small Molecule - Antagonist

Product Number
Description
Species
1α,25-Dihydroxyvitamin D3, ≥99% (HPLC),
Species
human
1α,25-Dihydroxyvitamin D3, ≥97.0% (HPLC),
Species
human

Antibodies

Product Number
Description
Species Reactivity
Application
Anti-VDR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Species Reactivity
human
Application
immunofluorescence
Anti-VDR antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody,
Species Reactivity
human
Application
immunofluorescence
Anti-Vitamin D Receptor (Ab-1) Rat mAb (9A7γE10.4), liquid, clone 9A7γE10.4, Calbiochem®,
Species Reactivity
amphibian, chicken, hamster, human, mouse, porcine, rat
Application
Anti-VDR Antibody, clone 2R1F6, Rabbit Monoclonal, ,
Species Reactivity
mouse
Application
western blot
Anti-Vitamin D3 Receptor Antibody, clone 1M19 ZooMAb® Rabbit Monoclonal, recombinant, expressed in HEK 293 cells,
Species Reactivity
bovine, canine, feline, human, monkey, mouse, porcine, rat
Application
affinity binding assay
immunocytochemistry

immunohistochemistry

western blot

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human VDR,
Species
human