C8749

Copeptin trifluoroacetate human

≥95% (HPLC)

• Synonym(s): H-Ala-Ser-Asp-Arg-Ser-Asn-Ala-Thr-Gln-Leu-Asp-Gly-Pro-Ala-Gly-Ala-Leu-Leu-Leu-Arg-Leu-Val-Gln-Leu-Ala-Gly-Ala-Pro-Glu-Pro-Phe-Glu-Pro-Ala-Gln-Pro-Asp-Ala-Tyr-OH trifluoroacetate
• Empirical Formula (Hill Notation): C₁₇₇H₂₇₉N₄₉O₅₈ · xC₂HF₃O₂
• CAS Number: 78362-34-2
• Molecular Weight: 4021.40 (free base basis)
• NACRES: NA.32
• PubChem Substance ID: 329775187
• UNSPSC Code: 51111800
• MDL number: MFCD18782466

Properties

• biological source: human
• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: film or powder
• color: colorless to light yellow
• solubility: H₂O: >1 mg/mL
• storage temp.: −20°C
• SMILES string: OC(=O)C(F)(F)F.CC(C)C[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)N)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](C)C(=O)N2CCC[C@H]2C(=O)N[C@@H](CCC(O)=O)C(=O)N3CCC[C@H]3C(=O)N[C@@H](Cc4ccccc4)C(=O)N[C@@H](CCC(O)=O)C(=O)N5CCC[C@H]5C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N6CCC[C@H]6C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc7ccc(O)cc7)C(O)=O
• InChI: 1S/C177H279N49O58.C2HF3O2/c1-81(2)64-107(152(260)194-89(16)141(249)190-77-131(236)193-95(22)171(279)223-60-30-40-123(223)166(274)205-106(51-56-134(240)241)174(282)226-63-32-41-124(226)167(275)215-113(70-97-34-25-24-26-35-97)159(267)204-105(50-55-133(238)239)173(281)224-61-31-39-122(224)165(273)198-93(20)144(252)203-104(49-54-128(181)233)172(280)225-62-33-42-125(225)168(276)216-116(74-136(244)245)154(262)195-92(19)145(253)217-118(175(283)284)71-98-43-45-99(230)46-44-98)207-150(258)102(47-52-126(179)231)201-169(277)138(87(13)14)220-161(269)112(69-86(11)12)209-148(256)100(36-27-57-187-176(183)184)199-155(263)109(66-83(5)6)210-157(265)111(68-85(9)10)211-156(264)108(65-82(3)4)206-143(251)91(18)192-130(235)76-189-142(250)90(17)197-164(272)121-38-29-59-222(121)132(237)78-191-147(255)115(73-135(242)243)213-158(266)110(67-84(7)8)208-151(259)103(48-53-127(180)232)202-170(278)139(96(23)229)221-146(254)94(21)196-153(261)114(72-129(182)234)212-163(271)120(80-228)219-149(257)101(37-28-58-188-177(185)186)200-160(268)117(75-137(246)247)214-162(270)119(79-227)218-140(248)88(15)178;3-2(4,5)1(6)7/h24-26,34-35,43-46,81-96,100-125,138-139,227-230H,27-33,36-42,47-80,178H2,1-23H3,(H2,179,231)(H2,180,232)(H2,181,233)(H2,182,234)(H,189,250)(H,190,249)(H,191,255)(H,192,235)(H,193,236)(H,194,260)(H,195,262)(H,196,261)(H,197,272)(H,198,273)(H,199,263)(H,200,268)(H,201,277)(H,202,278)(H,203,252)(H,204,267)(H,205,274)(H,206,251)(H,207,258)(H,208,259)(H,209,256)(H,210,265)(H,211,264)(H,212,271)(H,213,266)(H,214,270)(H,215,275)(H,216,276)(H,217,253)(H,218,248)(H,219,257)(H,220,269)(H,221,254)(H,238,239)(H,240,241)(H,242,243)(H,244,245)(H,246,247)(H,283,284)(H4,183,184,187)(H4,185,186,188);(H,6,7)/t88-,89-,90-,91-,92-,93-,94-,95-,96+,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,113-,114-,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,138-,139-;/m0./s1
• InChI key: PBRJDIQIICROHQ-URAAVIGWSA-N

Description

Biochem/physiol Actions

Copeptin, the C-terminal part of the vasopressin prohormone is a stable and sensitive surrogate marker for AVP release.

Copeptin, the C-terminal part of the vasopressin prohormone is a stable and sensitive surrogate marker for AVP release. Copeptin, a 39-amino acid glycopeptide that comprises the C-terminal part of the Arginine vasopressin (AVP) precursor (CT-proAVP), is cosynthesized with AVP. AVP is a primary secretagogue of the hypothalamo–pituitary–adrenal axis, a key hormone for maintaining fluid balance and vascular tone, and is a marker of acute endogenous stress. However, it has a short half-life and measurement of mature AVP is difficult and subject to errors. Copeptin in contrast is stable and easily measured.

Safety Information

• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable