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Merck

C5VP001A

Cellicon® Filter Assembly with Durapore® Membrane

filtration area 0.01 m2

Synonym(s):

Cellicon® Perfusion Filter with Durapore® Membrane

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About This Item

UNSPSC Code:
42294704

Key Documents

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material

PET support
PVDF
polyester support

Quality Level

400

Agency

meets USP Biological Reactivity Test for class VI plastics (family component materials)

sterility

sterile; γ-irradiated (level of 25-40kGy)

flow rate measuring range

10 L/min (/m2)

parameter

1 psi max. reverse press. exposure at 25 °C
1-2.5 L process volume
15 psi at 25 °C (max. burst pressure)
5 psi max. inlet pressure at 25 °C

filtration area

0.01 m2

membrane filtration area

0.01 m2

pore size

5 μm pore size

storage temp.

15-25°C

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General description

Housing/Overmold/ Assembly fittings/Single-use pump head: Polypropylene; Feed screen: Polyethylene terephthalate (PET); Polyester; Tubing: AdvantaFlex (Thermoplastic Elastomer), DOW Pharma 65; Feed screen: Polyethylene terephthalate (PET); Polyester; Pressure sensors: Polysulfone; Cable ties: Nylon
The Cellicon® Perfusion Filter is designed to meet your perfused seed train challenges. It is a flat sheet cell retention filter running in tangential flow filtration mode part of a single-use assembly. Perfusion operations deliver high-density cell cultures that alleviate the burden of processing large production bioreactor volumes while increasing manufacturing flexibility. Introducing perfusion to your seed train makes it possible to inoculate a higher quantity of cells for one or more production bioreactors, thus increasing process efficiency.

Application

Microfiltration
Seed Train Perfusion

Features and Benefits

High throughput. Predictable linear scale up from lab to manufacturing scale. Reliable and reproducible performance. Low crossflow and cell shear.

Other Notes

These products are manufactured in a facility which adheres to Good Manufacturing Practices.

Legal Information

CELLICON is a registered trademark of Merck KGaA, Darmstadt, Germany
Durapore is a registered trademark of Merck KGaA, Darmstadt, Germany

Certificates of Analysis (COA)

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Articles

Cell Retention Technology and Specialized Cell Culture Media for Intensified Upstream Processing

How the Cellicon® filter and controller enables seamless adoption of a perfused N-1 seed train step into the cell expansion process.

Extractables and Leachables Risk Assessment for Single-Use Systems

Before adoption of single-use technologies in biomanufacturing, manufacturers must assess the risk to the drug product from potential leachables. This article highlights a general approach based on the United States Pharmacopeia (USP).

Optimizing CHO Cells for Higher Productivity

Cellvento 4CHO-X Expansion Medium enhances cell biomass for bioreactor inoculation in cell expansion stages.

Operational and Financial Advantages of Cellicon® Cell Retention Solution in an N-1 Perfusion Process

This page describes the financial and operational advantages offered by the Cellicon® Cell Retention Device in an N-1 perfusion process at the 2,000 L scale in comparison to a cell retention device from another supplier.

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Production and Harvest Intensification

Biopharmaceutical developers need efficient, productive upstream processes that deliver high quality monoclonal antibodies (mAbs) and other types of recombinant proteins. Process intensification can future-proof their manufacturing strategies, reduce costs, and increase facility flexibility.

Seed Train Intensification

Biopharmaceutical developers need efficient, productive upstream processes that deliver high quality monoclonal antibodies (mAbs) and other types of recombinant proteins. Process intensification can future-proof their manufacturing strategies, reduce costs, and increase facility flexibility.

Tăng cường sản xuất và thu hoạch

Các nhà phát triển dược phẩm sinh học cần các quá trình ngược dòng hiệu quả, hiệu quả cung cấp các kháng thể đơn dòng chất lượng cao (mAbs) và các loại protein tái tổ hợp khác. Tăng cường quy trình có thể chứng minh cho các chiến lược sản xuất của họ trong tương lai, giảm chi phí và tăng tính linh hoạt của nhà máy.

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