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Merck

A6283

Acetic acid

glacial, ReagentPlus®, ≥99%

Acetic acid
1 of 3 reviewers received a sample product or took part in a promotion

Synonym(s):

Glacial acetic acid

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About This Item

Linear Formula:
CH3CO2H
CAS Number:
Molecular Weight:
60.05
Beilstein:
506007
EC Number:
MDL number:
UNSPSC Code:
12352106
PubChem Substance ID:
NACRES:
NA.21

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vapor density

2.07 (vs air)

Quality Level

product line

ReagentPlus®

Assay

≥99%

form

liquid

autoignition temp.

800 °F

expl. lim.

16 %, 92 °F
4 %, 59 °F

refractive index

n20/D 1.371 (lit.)

pH

2.5 (20 °C, 50 g/L)

bp

117-118 °C (lit.)

mp

16.2 °C (lit.)

solubility

alcohol: miscible(lit.)
carbon disulfide: insoluble(lit.)
glycerol: miscible(lit.)
water: miscible(lit.)

density

1.04 g/mL at 25 °C (lit.)

storage temp.

room temp

SMILES string

[F2C(F2C)13F3C]C(O)=O

InChI

1S/C2H4O2/c1-2(3)4/h1H3,(H,3,4)

InChI key

QTBSBXVTEAMEQO-UHFFFAOYSA-N

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1 of 4

This Item
3320927225W200603
assay

≥99%

assay

≥99.8%

assay

99.8-100.5%

assay

≥99.5%

Quality Level

200

Quality Level

200

Quality Level

200

Quality Level

400

form

liquid

form

liquid

form

liquid

form

liquid

solubility

alcohol: miscible(lit.), glycerol: miscible(lit.), carbon disulfide: insoluble(lit.), water: miscible(lit.)

solubility

-

solubility

-

solubility

-

pH

2.5 (20 °C, 50 g/L)

pH

2.5 (20 °C, 50 g/L)

pH

2.5 (20 °C, 50 g/L)

pH

2.5 (20 °C, 50 g/L)

storage temp.

room temp

storage temp.

room temp

storage temp.

-

storage temp.

-

General description

Acetic acid is an aliphatic organic acid.[1] It is a hygroscopic, corrosive liquid with a vinegar-like odor.[1][2] It can be synthesized by oxidizing acetaldehyde in the presence of manganese or cobalt salts.[2] It is utilized for synthesizing acetic anhydride, cellulose acetate and acetic esters.[2] Its impact on the degradation of historic paper has been analyzed.[3]

Application

Acetic acid (AcOH) can be used as:      
  • A reaction solvent in many organic reactions such as bromination, hydrolysis, solvolysis, reductions, and hydrogenations.      
  • A reagent in the protonolysis of organometallic compounds.
  • An acetylating agent for the acetylation of electron-rich aromatic compounds.      
  • A catalyst to synthesize di(indolyl)methanes by the condensation reaction of indole and aromatic aldehydes.      
  • A solvent system to prepare 3,4-dihydropyrimidin-2(1H)-one derivative via Biginelli reaction of aromatic aldehydes, 1,3-dicarbonyl compounds, and urea in the presence of a boric acid catalyst.

Acetic acid can also be used in the following:     
  • Manganese(III) acetate/AcOH catalytic system is used in the conversion of alkenes to lactones.      
  • Iron salts/AcOH is used to oxidize 2-methylnaphthalene to 2-methyl-1-naphthol in the presence of H2O2.

Features and Benefits

  • Good stability towards many reagents     
  • Excellent solubility of organic compounds in this reagent

Legal Information

ReagentPlus is a registered trademark of Merck KGaA, Darmstadt, Germany

Pictograms

FlameCorrosion

Signal Word

Danger

Hazard Statements

Hazard Classifications

Eye Dam. 1 - Flam. Liq. 3 - Skin Corr. 1A

Storage Class Code

3 - Flammable liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Maize Kernels-Fixation in FAA, Embedding, Sectioning and Feulgen Staining.
Kladnik A.
Bio-protocol, 3(15), e835-e835 (2013)
Thermooxidative aging of polydicyclopentadiene in glassy state.
Richaud E, et al.
Polymer Degradation and Stability, 102, 95-104 (2014)
Effects of NO2 and acetic acid on the stability of historic paper.
Menart Eet al.
Cellulose, 21(5), 3701-3713 (2014)
Ash M and Ash I.
Handbook of Preservatives, 266-266 (2004)
Acetic acid catalyzed carbon aerogels.
Brandt R, et al.
Journal of Porous Materials, 10(3), 171-178 (2003)

Protocols

Preparation of Plasmid DNA by Alkaline Lysis with SDS: Maxipreparation between Cold Spring Harbor Laboratory Press and our research team.

Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

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  2. is ReagentPlus (acid acetic) suitable for HPLC - UV ? as "100%, for HPLC LiChropur"

    1 answer
    1. With a guaranteed purity of ≥98.5%, this product is suitable for general laboratory use, including trial synthesis and preparation. Although not specifically designed for analytical applications, it can be utilized in such contexts. However, it is recommended to use a solvent specifically suitable for HPLC or analytical grade applications.

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  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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