Skip to Content
Merck

47608

Formaldehyde solution

Molecular Biology, BioReagent, ≥36.0% in H2O (T)

Synonym(s):

Formic aldehyde, Formol, Formalin

Slide 1 of 1
Sign In to View Organizational & Contract Pricing

Select a Size

Pricing and availability is not currently available.

About This Item

Linear Formula:
HCHO
CAS Number:
50-00-0
Molecular Weight:
30.03
Beilstein:
1209228
MDL number:
MFCD00003274
UNSPSC Code:
12352114
PubChem Substance ID:
329757328
NACRES:
NA.52
Grade:
Molecular Biology
Technique(s):
electrophoresis: suitable
Vapor pressure:
52 mmHg ( 37 °C)

Key Documents

View All Documentation

Skip To

Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

grade

Molecular Biology

Quality Level

100

vapor density

1.03 (vs air)

vapor pressure

52 mmHg ( 37 °C)

product line

BioReagent

form

liquid

autoignition temp.

572 °F

contains

~10% methanol as stabilizer

concentration

≥36.0% in H2O (T)
36.0-38.0% (aldehyde method)

technique(s)

electrophoresis: suitable

impurities

≤0.03% free acid (as HCOOH)

ign. residue

≤0.05% (as SO4)

pH

2.8-4.0

density

1.09 g/mL at 20 °C
1.09 g/mL at 25 °C (lit.)

anion traces

chloride (Cl-): ≤10 mg/kg
sulfate (SO42-): ≤20 mg/kg

cation traces

Ca: ≤5 mg/kg
Cd: ≤1 mg/kg
Co: ≤1 mg/kg
Cr: ≤1 mg/kg
Cu: ≤1 mg/kg
Fe: ≤1 mg/kg
K: ≤20 mg/kg
Mg: ≤1 mg/kg
Mn: ≤1 mg/kg
Na: ≤100 mg/kg
Ni: ≤1 mg/kg
Pb: ≤1 mg/kg
Zn: ≤1 mg/mL

λ

2 M in H2O

UV absorption

λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01

suitability

in accordance for electrophoresis of RNA in agarose gels

storage temp.

room temp

SMILES string

[H]C([H])=O

InChI

1S/CH2O/c1-2/h1H2

InChI key

WSFSSNUMVMOOMR-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item
F877547083-U1.04003
Formaldehyde solution Molecular Biology, BioReagent, ≥36.0% in H2O (T)

Sigma-Aldrich

47608

Formaldehyde solution

Formaldehyde solution Molecular Biology, 36.5-38% in H2O

Sigma-Aldrich

F8775

Formaldehyde solution

Formaldehyde solution stabilized with methanol, ~37 wt. % in H2O, certified reference material

Supelco

47083-U

Formaldehyde solution

Formaldehyde solution about 37% GR for analysis stabilized with about 10% methanol ACS,Reag. Ph Eur

Sigma-Aldrich

1.04003

Formaldehyde solution about 37%

technique(s)

electrophoresis: suitable

technique(s)

ChIP: suitable, immunofluorescence: suitable, immunohistochemistry: suitable

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

technique(s)

-

grade

for molecular biology

grade

for molecular biology

grade

certified reference material

grade

ACS reagent

Quality Level

100

Quality Level

100

Quality Level

300

Quality Level

400

form

liquid

form

liquid

form

-

form

liquid

density

1.09 g/mL at 20 °C, 1.09 g/mL at 25 °C (lit.)

density

1.09 g/mL at 25 °C (lit.)

density

1.09 g/mL at 25 °C (lit.)

density

1.09 g/cm3 at 20 °C, 1.09 g/mL at 25 °C (lit.)

cation traces

Ca: ≤5 mg/kg, Co: ≤1 mg/kg, Cu: ≤1 mg/kg, K: ≤20 mg/kg, Mn: ≤1 mg/kg, Ni: ≤1 mg/kg, Zn: ≤1 mg/mL, Cd: ≤1 mg/kg, Fe: ≤1 mg/kg, Na: ≤100 mg/kg, Cr: ≤1 mg/kg, Pb: ≤1 mg/kg, Mg: ≤1 mg/kg

cation traces

-

cation traces

-

cation traces

-

General description

Formaldehyde is a molecular biology reagent that denaturates RNA during electrophoresis when incorporated in agarose gels.
It is an aliphatic aldehyde that is widely used in industrial applications for the synthesis of several chemicals such as melamine formaldehyde, urea-formaldehyde, phenol formaldehyde and industrial resins, paraformaldehyde, polyols, chelating agents, slow release fertilizers, 1,4-butanediol and hexamethylenetetramine.[1]

Application

Formaldehyde solution is suitable for:
  • denaturation and separation of RNA molecules
  • anti-bacterial treatment
  • fixation of cells
Formaldehydesolution has been used:
  • in the fixation of human spermatogonial stem cell transplantation (SSCT).[2]
  • to crosslink T- cell acute lymphoblastic leukemia protein/DNA complex during chromatin immunoprecipitation.[3]
  • in fixing zebra fish larvae for neutrophil staining.[4]

Biochem/physiol Actions

Formaldehyde disrupts the secondary structure of RNA and allows separation and identification of RNA species based on charge migration.

Disclaimer

may contain precipitate (paraformaldehyde)

Signal Word

Danger

Hazard Classifications

Acute Tox. 2 Inhalation - Acute Tox. 3 Dermal - Acute Tox. 3 Oral - Carc. 1B - Eye Dam. 1 - Flam. Liq. 3 - Muta. 2 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 1 - STOT SE 3

Target Organs

Eyes,Central nervous system, Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 3

Flash Point(F)

133.0 °F - closed cup

Flash Point(C)

56.11 °C - closed cup

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
BCCN1938
BCCM9304
BCCM0733
BCCL7726
BCCL1095

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Testicular tissue cryopreservation is the preferred method to preserve spermatogonial stem cells prior to transplantation
Onofre J, et al.
Reproductive Biomedicine Online, 40(2), 261-269 (2020)
Formaldehyde
Gerberich, H R and Seaman, G C.
Kirk-Othmer Encyclopedia of Chemical Technology (2013)
Jin Qian et al.
Virology, 474, 10-18 (2014-12-03)
Interferon-induced transmembrane (IFITM) proteins inhibit the entry of a large number of viruses. Not surprisingly, many viruses are refractory to this inhibition. In this study, we report that different strains of HIV and SIV are inhibited by human IFITM proteins
Y Jiang et al.
Oncogene, 34(50), 6079-6091 (2015-03-10)
Epstein-Barr virus (EBV) causes human lymphoid malignancies, and the EBV product latent membrane protein 1 (LMP1) has been identified as an oncogene in epithelial carcinomas such as nasopharyngeal carcinoma (NPC). EBV can epigenetically reprogram lymphocyte-specific processes and induce cell immortalization.
John N Griffin et al.
PLoS genetics, 11(3), e1005018-e1005018 (2015-03-11)
The production of ribosomes is ubiquitous and fundamental to life. As such, it is surprising that defects in ribosome biogenesis underlie a growing number of symptomatically distinct inherited disorders, collectively called ribosomopathies. We previously determined that the nucleolar protein, NOL11
View All Related Papers

Articles

3D Organoid Culture: New in vitro Model of Development and Disease (ấn bản 2)

Các sản phẩm nuôi cấy Organoid để tạo ra mô và tế bào gốc có nguồn gốc từ 3D não, ruột, ruột, phổi và ung thư mô hình organoid khối u.

Cellular Fluorescence Imaging with Millicell® Cell Culture Inserts

Millicell® hanging cell culture inserts for staining and microscopic analysis directly from the insert. Learn to utilize hanging cell culture inserts in barrier measurements.

3D Organoid Culture: New In Vitro Models of Development and Disease

Organoid culture products to generate tissue and stem cell derived 3D brain, intestinal, gut, lung and cancer tumor organoid models.

Related Content

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service