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Expert opinion on drug delivery

Dextran conjugates in drug delivery.


PMID 22432550

Abstract

Dextran is a family of natural polysaccharides that is widely under investigation for use as polymeric carriers in novel drug delivery systems. The optimal drug delivery (and consequently maximum therapeutic effect) will be accomplished when carrier systems are used mainly for drugs with antitumoral activity, as they increase their blood permanence time, taking advantage of the increased mass that reduces kidney ultrafiltration. This review summarizes the attempts that have been made in the development of dextran conjugates and their application. The manuscript describes dextran hydrogels, the use of conjugates of dextran in bioadhesive oral delivery systems, colon drug delivery, reduction of ulcerogenicity of drugs, production of micelles, solubilization, long-circulating pharmaceutical carriers as anticancer drug carriers, non-viral vectors, stabilization of enzymes, functionalization of nanomaterials, diagnosis of solid tumors and hyperthermic treatment and liver targeting. Dextran conjugation has aided the design of new tailor-made polymers with different molecular weights, shapes, structures and with the functional groups needed for coupling at the desired positions in the chain. Dextran prodrugs are very useful systems for achieving controlled drug release and drug targeting. In particular, various dextran-antitumor drug conjugates enhance the effectiveness and improve the cytotoxic effects of chemotherapeutic agents. Future studies should concentrate on barriers for their clinical use and safety as a drug carrier.

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00268 Dextran, analytical standard, for GPC, 1,000
00269 Dextran, analytical standard, for GPC, 5,000
00270 Dextran, analytical standard, for GPC, 12,000
00271 Dextran, analytical standard, for GPC, 25,000
00891 Dextran, analytical standard, for GPC, 50,000
00892 Dextran, analytical standard, for GPC, 80,000
00893 Dextran, analytical standard, for GPC, 150,000
00894 Dextran, analytical standard, for GPC, 270,000
00895 Dextran, analytical standard, for GPC, 410,000
00896 Dextran, analytical standard, for GPC, 670,000
31430 Dextran, analytical standard, for GPC, Set Mp 1,000-400,000
D0731000 Dextran, European Pharmacopoeia (EP) Reference Standard
D0731005 Dextran 1, European Pharmacopoeia (EP) Reference Standard
D0734000 Dextran 10 for calibration, European Pharmacopoeia (EP) Reference Standard
D0737000 Dextran 250 for calibration, European Pharmacopoeia (EP) Reference Standard
D0733000 Dextran 4 for calibration, European Pharmacopoeia (EP) Reference Standard
D0735000 Dextran 40 for calibration, European Pharmacopoeia (EP) Reference Standard
D0738000 Dextran 40 for performance test, European Pharmacopoeia (EP) Reference Standard
D0739000 Dextran 60/70 for performance test, European Pharmacopoeia (EP) Reference Standard
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31416 Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 1,000
31417 Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 5,000
31418 Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 12,000
31419 Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 25,000
31420 Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 50,000
31421 Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 80,000
31422 Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 150,000
31423 Dextran from Leuconostoc mesenteroides, for GPC, Mw 270,000
31424 Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 410,000
31425 Dextran from Leuconostoc mesenteroides, analytical standard, for GPC, Mw 670,000