67070
1-Methylguanine
≥95%
Synonym(s):
2-Amino-6-hydroxy-1-methylpurine
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About This Item
Empirical Formula (Hill Notation):
C6H7N5O
CAS Number:
Molecular Weight:
165.15
Beilstein/REAXYS Number:
149730
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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assay
≥95%
mp
≥300 °C
SMILES string
CN1C(N)=Nc2[nH]cnc2C1=O
InChI
1S/C6H7N5O/c1-11-5(12)3-4(9-2-8-3)10-6(11)7/h2H,1H3,(H2,7,10)(H,8,9)
InChI key
RFLVMTUMFYRZCB-UHFFFAOYSA-N
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Pål Ø Falnes
Nucleic acids research, 32(21), 6260-6267 (2004-12-04)
The Escherichia coli AlkB protein repairs 1-methyladenine (1-meA) and 3-methylcytosine (3-meC) lesions in DNA and RNA by oxidative demethylation, a reaction requiring ferrous iron and 2-oxoglutarate as cofactor and co-substrate, respectively. Here, we have studied the activity of AlkB proteins
Increases in methylated nucleosides during human pregnancy.
R J Simmonds et al.
Advances in experimental medicine and biology, 165 Pt A, 291-295 (1984-01-01)
C Hanski et al.
Cell and tissue research, 241(1), 203-206 (1985-01-01)
1-Methylguanine and 7-methylguanine, both metabolic products of tRNA degradation, are known to induce transformation of Chinese hamster fibroblasts in culture. The effects of these compounds on the cell membrane have been studied by the method of Concanavalin A-mediated hemadsorption. 1-Methylguanine
S J Kerr
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 6(2), 123-131 (1985-01-01)
Primary Chinese hamster embryo cultures exposed chronically to 1-methylguanine or 7-methylguanine, modified purines derived from nucleic acid turnover, exhibit a number of properties characteristic of transformed cell lines. One of the earliest effects observed following exposure of cells to the
S J Kerr
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 6(2), 115-121 (1985-01-01)
1-Methylguanine and 7-methylguanine are naturally occurring modified purines derived from tRNA, found in elevated levels in the serum and urine of cancer patients. When C3H/10T1/2 clone-8 mouse cells are exposed to low levels of the methylated purines, they are induced
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