04635

Metformin hydrochloride

pharmaceutical secondary standard; traceable to USP and PhEur

• Synonym(s): 1,1-Dimethylbiguanide hydrochloride, Metformin
• Linear Formula: NH₂C(=NH)NHC(=NH)N(CH₃)₂ · HCl
• CAS Number: 1115-70-4
• Molecular Weight: 165.62
• UNSPSC Code: 41116107
• PubChem Substance ID: 329747963
• EC Number: 214-230-6
• MDL number: MFCD00012582
• eCl@ss: 25140904

Properties

• grade: certified reference material, pharmaceutical secondary standard
• agency: traceable to Ph. Eur. M0605000, traceable to USP 1396309
• mp: 223-226 °C (lit.)
• application(s): clinical testing
• format: neat
• storage temp.: 2-8°C
• SMILES string: Cl[H].CN(C)C(=N)NC(N)=N
• InChI: 1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H
• InChI key: OETHQSJEHLVLGH-UHFFFAOYSA-N
• Gene Information: —

Description

Biochem/physiol Actions

Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302,H319
• Precautionary Statements: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Hazard Classifications: Acute Tox. 4 Oral - Eye Irrit. 2
• Storage Class: 11 - Combustible Solids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable