A7252

Ajmaline

• Empirical Formula (Hill Notation): C₂₀H₂₆N₂O₂
• CAS Number: 4360-12-7
• Molecular Weight: 326.43
• UNSPSC Code: 41116107
• EC Number: 224-439-4
• MDL number: MFCD00135652
• eCl@ss: 32150313

Properties

• storage temp.: 2-8°C
• SMILES string: CCC1C(O)N2C3CC1C4C(O)C5(CC24)[C@H]3N(C)c6ccccc56

Description

Biochem/physiol Actions

Indole alkaloid from Rauwolfia serpentina that is a Class Ia antiarrhythmia compound. It blocks sodium channels in skeletal and cardiac muscle and cardiac HERG potassium channels in the open state but not in the closed state. Ajmaline administered intravenously prolongs the atrioventricular (AV) conduction times in the heart and has been used diagnostically to detect AV block and other cardiac abnormalities.

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302
• Precautionary Statements: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Faceshields, Gloves