C7491

Anti-CFTR antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-Cystic Fibrosis Transmembrane Conductance Regulator
• UNSPSC Code: 12352203
• NACRES: NA.41
• MDL number: MFCD01321917
• Conjugate: unconjugated
• Clone: polyclonal
• Application: ICC
• Citations: 5

Properties

• biological source: rabbit
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): immunocytochemistry: 1 μg/mL using HEK293 cells overexpressing human CFTR
• UniProt accession no.: P13569
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: unmodified
• Gene Information: human ... CFTR(1080) ; rat ... Cftr(24255)

Description

General description

CFTR (Cystic fibrosis transmembrane conductance regulator, ATP-binding cassette sub-family C, member 7) is a membrane-associated, N-linked glycoprotein.

Immunogen

synthetic peptide corresponding to amino acids 103-117 of human CFTR protein. The sequence is 100% conserved in human, rabbit, and monkey. There is a one amino acid substitution in rat, bovine, and sheep.

Application

Anti-CFTR antibody produced in rabbit is suitable for immunocytochemistry at a concentration of 1μg/mL using HEK293 cells overexpressing human CFTR.

Biochem/physiol Actions

Cystic fibrosis transmembrane conductance regulator (CFTR) gene is associated with congenital bilateral absence of the vas deferens (CBAVD) and causes the genital form of cystic fibrosis (CF). The CFTR gene may also be involved in the etiology of male infertility. It may be useful for assisting reproduction technology. There is nearly 2000 cystic fibrosis transmembrane regulator (CFTR) mutations that are associated with cystic fibrosis (CF).

Physical form

Solution in phosphate buffered saline containing 1.0 mg/mL bovine serum albumin and 0.05 % sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Safety Information

• Storage Class: 10 - Combustible liquids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable
• PPE (personal protective equipment): Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)