M2901

Molsidomine

• Synonym(s): N-(Ethoxycarbonyl)-3-(4-morpholino)sydnone imine, SIN-10
• Empirical Formula (Hill Notation): C₉H₁₄N₄O₄
• CAS Number: 25717-80-0
• Molecular Weight: 242.23
• NACRES: NA.77
• PubChem Substance ID: 24278544
• UNSPSC Code: 12352200
• EC Number: 247-207-4
• MDL number: MFCD00869301

Properties

• storage temp.: 2-8°C
• SMILES string: CCOC(=O)N=C1O[N-][N+](=C1)N2CCOCC2
• InChI: 1S/C9H14N4O4/c1-2-16-9(14)10-8-7-13(11-17-8)12-3-5-15-6-4-12/h7H,2-6H2,1H3/b10-8-
• InChI key: XLFWDASMENKTKL-NTMALXAHSA-N

Description

Application

Molsidomine has been used as nitric oxide (NO)-releasing vasodilator to study the effect of NO on angiostatin production in aging rat kidneys.

Biochem/physiol Actions

Molsidomine is an effective vasodilator and a long-lasting nitric oxide (NO) donor. It is a pro-drug that is enzymatically decarboxylated to form 3-morpholinosydnone imine (SIN-1) in the liver. Molsidomine is used as an anti-anginal agent and possesses antioxidant properties. It may be used to treat cisplatin-induced oxidative stress in the liver tissue. Molsidomine has also been used during angina pectoris, heart failure, and after myocardial infarction.

Orally active, long acting vasodilator; antianginal; converted by the liver to the active metabolite, SIN-1

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Codes: H302
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class: 11 - Combustible Solids
• WGK: WGK 3
• PPE (personal protective equipment): dust mask type N95 (US), Eyeshields, Gloves