ALX4
ALX homeobox 4
同義詞:
FND2
物種:
Human ALX4 (60529), Mouse Alx4 (11695), Rat Alx4 (296511), cow ALX4 (594846), chicken ALX4 (373976), domestic guinea pig Alx4 (100715494), naked mole-rat Alx4 (101715465), sheep ALX4 (101116426), dog ALX4 (609979), domestic cat ALX4 (101083878)
UniProtKB ID:
基因 ID:
- Human(60529) Summary: This gene encodes a paired-like homeodomain transcription factor expressed in the mesenchyme of developing bones, limbs, hair, teeth, and mammary tissue. Mutations in this gene cause parietal foramina 2 (PFM2); an autosomal dominant disease characterized by deficient ossification of the parietal bones. Mutations in this gene also cause a form of frontonasal dysplasia with alopecia and hypogonadism; suggesting a role for this gene in craniofacial development, mesenchymal-epithelial communication, and hair follicle development. Deletion of a segment of chromosome 11 containing this gene, del(11)(p11p12), causes Potocki-Shaffer syndrome (PSS); a syndrome characterized by craniofacial anomalies, mental retardation, multiple exostoses, and genital abnormalities in males. In mouse, this gene has been shown to use dual translation initiation sites located 16 codons apart. [provided by RefSeq, Oct 2009]
- Mouse(11695) aristaless-like homeobox 4
- Rat(296511) ALX homeobox 4
- cow(594846) ALX homeobox 4
- chicken(373976) ALX homeobox 4
- domestic guinea pig(100715494) ALX homeobox 4
- naked mole-rat(101715465) ALX homeobox 4
- sheep(101116426) ALX homeobox 4
- dog(609979) ALX homeobox 4
- domestic cat(101083878) ALX homeobox 4
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