PCDHA7
protocadherin alpha 7
동의어:
CNR4, CNRN4, CNRS4, CRNR4, PCDH-ALPHA7
종:
Human PCDHA7 (56141), Mouse Pcdha7 (12939), Rat Pcdha7 (393089), naked mole-rat Pcdha7 (101729229), domestic guinea pig Pcdha7 (100714152), chicken PCDHA7 (497217)
UniProtKB ID:
Clone ID:
- Human(56141) Summary: This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008]
- Mouse(12939) protocadherin alpha 7
- Rat(393089) protocadherin alpha 7
- naked mole-rat(101729229) protocadherin alpha 7
- domestic guinea pig(100714152) protocadherin alpha 7
- chicken(497217) protocadherin alpha 7
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