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Merck

PIK3CG

phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

Synonyms:
PI3CG, PI3K, PI3Kgamma, PIK3, p110gamma, p120-PI3K
Species:
UniProtKB ID:
Gene ID:
  • Human(5294) Summary: This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that phosphorylates phosphoinositides on the 3-hydroxyl group of the inositol ring. It is an important modulator of extracellular signals, including those elicited by E-cadherin-mediated cell-cell adhesion, which plays an important role in maintenance of the structural and functional integrity of epithelia. In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the regulation of cytotoxicity in NK cells. The gene is located in a commonly deleted segment of chromosome 7 previously identified in myeloid leukemias. [provided by RefSeq, Jul 2008]
  • Mouse(30955) phosphoinositide-3-kinase, catalytic, gamma polypeptide
  • Rat(298947) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
  • Zebrafish(406598) phosphoinositide-3-kinase, catalytic, gamma polypeptide
  • domestic guinea pig(100725386) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
  • Zebrafish(564261) phosphoinositide-3-kinase, catalytic, gamma polypeptide
  • dog(483266) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
  • sheep(101102896) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
  • domestic cat(101096215) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
  • cow(530001) phosphoinositide-3-kinase, catalytic, gamma polypeptide
  • chicken(417706) phosphoinositide-3-kinase, catalytic, gamma polypeptide
  • naked mole-rat(101707055) phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

Custom & Knockdown Gene Products

Small Molecule - Inhibitor

Product Number
Description
Species
Wortmannin, Ready Made Solution, from Penicillium funiculosum, ≥95% (HPLC),
Species
human
Wortmannin, from Penicillium funiculosum, ≥98% (HPLC and TLC),
Species
human

Proteins

Product Number
Description
Species
PI3 Kinase (p120γ), 20 µg, For use in Kinase Assays.,
Species
human

esiRNA

Product Number
Description
Species
MISSION® esiRNA, targeting human PIK3CG,
Species
human