Loncat ke Konten
Merck

RASA1

RAS p21 protein activator (GTPase activating protein) 1

Sinonim:
CM-AVM, CMAVM, GAP, PKWS, RASA, RASGAP, p120GAP, p120RASGAP
Spesies:
Human RASA1 (5921), Mouse Rasa1 (218397), Rat Rasa1 (25676), domestic cat RASA1 (101095151), naked mole-rat Rasa1 (101713771), cow RASA1 (282032), domestic guinea pig Rasa1 (100726441), dog RASA1 (479158), sheep RASA1 (101119216), chicken RASA1 (427327)
ID UniProtKB:
P20936, B2R6W3, Q9UDI1
ID Gen:
  • Human(5921) Summary: The protein encoded by this gene is located in the cytoplasm and is part of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. Mutations leading to changes in the binding sites of either protein are associated with basal cell carcinomas. Mutations also have been associated with hereditary capillary malformations (CM) with or without arteriovenous malformations (AVM) and Parkes Weber syndrome. Alternative splicing results in two isoforms where the shorter isoform, lacking the N-terminal hydrophobic region but retaining the same activity, appears to be abundantly expressed in placental but not adult tissues. [provided by RefSeq, May 2012]
  • Mouse(218397) RAS p21 protein activator 1
  • Rat(25676) RAS p21 protein activator (GTPase activating protein) 1
  • domestic cat(101095151) RAS p21 protein activator (GTPase activating protein) 1
  • naked mole-rat(101713771) RAS p21 protein activator (GTPase activating protein) 1
  • cow(282032) RAS p21 protein activator (GTPase activating protein) 1
  • domestic guinea pig(100726441) RAS p21 protein activator (GTPase activating protein) 1
  • dog(479158) RAS p21 protein activator (GTPase activating protein) 1
  • sheep(101119216) RAS p21 protein activator (GTPase activating protein) 1
  • chicken(427327) RAS p21 protein activator (GTPase activating protein) 1

Produk Gen Khusus & Knockdown

  • siRNA

    Belanja siRNA yang telah dirancang sebelumnya yang dirancang menggunakan algoritme Rosetta Inpharmatics yang eksklusif.

  • shRNA

    Beli koleksi shRNA terbesar dan tervalidasi dan buat set klon Anda sendiri.

  • Produk Gen Khusus

    Kami menawarkan portofolio lengkap oligos DNA, oligos RNA, dan primer yang telah dirancang sebelumnya.