WWOX
WW domain containing oxidoreductase
Sinónimos:
D16S432E, FOR, FRA16D, HHCMA56, PRO0128, SDR41C1, WOX1
Especie:
Human WWOX (51741), Mouse Wwox (80707), Rat Wwox (292041), dog WWOX (610120), domestic guinea pig Wwox (100722863), cow WWOX (618792), Horse WWOX (100055545), fruit fly Wwox (34090), Zebrafish wwox (393887), chicken WWOX (415801) ...Más
ID UniProtKB:
ID del gen:
- Human(51741) Summary: WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein which contains 2 WW domains and a short-chain dehydrogenase/reductase domain (SRD). The highest normal expression of this gene is detected in hormonally regulated tissues such as testis, ovary, and prostate. This expression pattern and the presence of an SRD domain suggest a role for this gene in steroid metabolism. The encoded protein is more than 90% identical to the mouse protein, which is an essential mediator of tumor necrosis factor-alpha-induced apoptosis, suggesting a similar, important role in apoptosis for the human protein. In addition, there is evidence that this gene behaves as a suppressor of tumor growth. Alternative splicing of this gene generates transcript variants that encode different isoforms. [provided by RefSeq, Jul 2008]
- Mouse(80707) WW domain-containing oxidoreductase
- Rat(292041) WW domain-containing oxidoreductase
- dog(610120) WW domain containing oxidoreductase
- domestic guinea pig(100722863) WW domain containing oxidoreductase
- cow(618792) WW domain containing oxidoreductase
- Horse(100055545) WW domain containing oxidoreductase
- fruit fly(34090) WW domain containing oxidoreductase
- Zebrafish(393887) WW domain containing oxidoreductase
- chicken(415801) WW domain containing oxidoreductase
- sheep(101120431) WW domain containing oxidoreductase
- naked mole-rat(101698327) WW domain containing oxidoreductase
- Domestic Rabbit(100353596) WW domain containing oxidoreductase
- domestic cat(101093411) WW domain containing oxidoreductase
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Antibodies
Número de producto
Descripción
Reactividad de especies
Aplicación
Anti-WWOX antibody produced in rabbit, Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution,
Reactividad de especies
human
Aplicación
immunofluorescence
immunohistochemistry
western blot
immunohistochemistry
western blot
Anti-WWOX Antibody, clone 12G5, clone 12G5, from rat,
Reactividad de especies
human, mouse
Aplicación
immunohistochemistry
western blot
western blot
Anti-phospho-WWOX (pTyr33) antibody produced in rabbit, affinity isolated antibody,
Reactividad de especies
human, mouse, rat
Aplicación
ELISA
immunohistochemistry
western blot
immunohistochemistry
western blot