SML2249
LSN3154567
≥98% (HPLC)
Synonym(s):
2-Hydroxy-2-methyl-N-[1,2,3,4-tetrahydro-2-[2-(3-pyridinyloxy)acetyl]-6-isoquinolinyl]-1-propanesulfonamide, Nampt-IN-1; 2-Hydoxy-2-methyl-N-{2-[(pyridin-3-yloxy)acetyl]-1,2,3,4-tetrahydroisoquinolin-6-YL}propane-1-sulfonamide
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About This Item
Empirical Formula (Hill Notation):
C20H25N3O5S
CAS Number:
Molecular Weight:
419.49
UNSPSC Code:
12352200
NACRES:
NA.77
MDL number:
Assay:
≥98% (HPLC)
Form:
powder
assay
≥98% (HPLC)
form
powder
color
white to beige
solubility
DMSO: 2 mg/mL, clear
storage temp.
2-8°C
SMILES string
[S](=O)(=O)(Nc1cc2c(cc1)CN(CC2)C(=O)COc3cnccc3)CC(O)(C)C
InChI
1S/C20H25N3O5S/c1-20(2,25)14-29(26,27)22-17-6-5-16-12-23(9-7-15(16)10-17)19(24)13-28-18-4-3-8-21-11-18/h3-6,8,10-11,22,25H,7,9,12-14H2,1-2H3
InChI key
QHHSCLARESIWBH-UHFFFAOYSA-N
Biochem/physiol Actions
LSN3154567 is an orally available, potent and highly selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT). LSN3154567 exhibits broad spectrum and potent anticancer activities without causing retinopathy in the rat. LSN3154567co-administration with nicotinic acid (NA) produces potent anti-tumor activity in tumor xenograft models without retinal and hematological toxicities.
LSN3154567 might be useful in developing a novel cancer therapeutic.
orally available, potent and highly selective inhibitor of nicotinamide phosphoribosyltransferase (NAMPT)
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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