SML2544

NSC49652

≥98% (HPLC)

• Synonim(y): (2E)-1-(2-Hydroxyphenyl)-3-(3-pyridinyl)-2-propen-1-one, (E)-1-(2-Hydroxyphenyl)-3-(pyridin-3-yl)-2-propen-1-one
• Wzór empiryczny (zapis Hilla): C₁₄H₁₁NO₂
• Numer CAS: 908563-68-8
• Masa cząsteczkowa: 225.24
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00499170
• Assay: ≥98% (HPLC)
• Form: powder

Właściwości

• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: OC1=CC=CC=C1C(/C=C/C2=CN=CC=C2)=O
• InChI: 1S/C14H11NO2/c16-13-6-2-1-5-12(13)14(17)8-7-11-4-3-9-15-10-11/h1-10,16H/b8-7+
• InChI key: CRWNZUBUBIULHB-BQYQJAHWSA-N

Opis

Biochem/physiol Actions

NSC49652 is a orally active, potent and selective inhibitor of death receptor p75NTR (p75 neurotrophin receptor) that targets the interfaces between transmembrane domains (TMDs). NSC49652 induces profound conformational changes and triggers p75NTR dependent cancer cell death. It inhibits the growth of cancer in melanoma mouse model.

orally active, potent and selective inhibitor of death receptor p75NTR that targets the interfaces between transmembrane domains

Ta strona może zawierać tekst przetłumaczony maszynowo.

Informacja o środkach bezpieczeństwa

• Klasa składowania: 11 - Combustible Solids
• Co się dzieje?: WGK 3
• Temperatura zapłonu (°F): Not applicable
• Temperatura zapłonu (°C): Not applicable