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ABN1469

Anti-Alpha-2-HS-Glycoprotein

from rabbit, purified by affinity chromatography

Synonym(s):

Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A, Alpha-2 Heremans-Schmid glycoprotein, AHGS

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25 μL
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$202.00
100 μL
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$534.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
eCl@ss:
32160702
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC, WB
Citations:
-

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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

purified by

affinity chromatography

species reactivity

human

packaging

antibody small pack of 25 μL

technique(s)

immunohistochemistry: suitable, western blot: suitable

NCBI accession no.

UniProt accession no.

target post-translational modification

unmodified

Gene Information

human ... AHSG(197)

General description

Alpha-2-HS-glycoprotein (UniProt: P02765; also known as Alpha-2-Z-globulin, Ba-alpha-2-glycoprotein, Fetuin-A, Alpha-2 Heremans-Schmid glycoprotein, AHSG) is encoded by the AHSG (also known as FETUA, PRO2743) gene (Gene ID: 197) in human. Alpha-2-HS-glycoprotein is a serum protein of the cystatin superfamily that is synthesized by hepatocytes and is considered as a negative acute-phase reactant. It is highly expressed in various fetal tissues, but in adults it is mainly expressed in the liver. It is synthesized with a signal peptide (aa 1-18) and a connective propeptide (aa 301-340) and is subsequently cleaved into 2 chains known as Alpha-2-HS-glycoprotein chain A and Alpha-2-HS-glycoprotein chain B. The mature product is involved in multiple normal biological and pathological functions. It promotes possesses opsonic properties and is shown to be involved in endocytosis, brain development, bone resorption, regulation of insulin activity and hepatocyte growth factor (HGF) activity. Alpha-2-HS-glycoprotein also serves as a carrier protein and serves as a carrier for otherwise insoluble calcium phosphate and can act as a potent inhibitor of pathological vascular calcification. Higher levels of Alpha-2-HS-glycoprotein have been reported in gestational and type II diabetes. It is also present at higher levels in patients with endometriosis. Lower levels of Alpha-2-HS-glycoprotein are present in cancer subjects. (Ref.: Kalabay, L., et al. (2002). Eur. J. Endocrinol. 147(2); 243-248; Sindhu, S., et al. (2016). BMC Immunol. 17; 33).
~55 kDa observed; 39.33 kDa calculated. Uncharacterized bands may be observed in some lysate(s).

Immunogen

Epitope: N-terminus
GST/His-tagged recombinant fragment corresponding to 146 amino acids from human Alpha-2-HS-glycoprotein.

Application

Anti-Alpha-2-HS-Glycoprotein Antibody, Cat. No. ABN1469, is a highly specific rabbit polyclonal antibody that targets Alpha-2-HS-Glycoprotein and has been tested for use Immunohistochemistry and Western Blotting.
Research Category
Neuroscience
Western Blotting Analysis: A 1:500 dilution from a representative lot detected Alpha-2-HS-Glycoprotein in human retina tissue lysate.

Immunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Alpha-2-HS-Glycoprotein in human liver and human bone marrow tissue sections.

Biochem/physiol Actions

This rabbit polyclonal antibody specifically detects human Alpha-2-HS-glycoprotein. It targets an epitope with in the N-terminal half.

Physical form

Affinity Purified
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Preparation Note

Stable for 1 year at 2-8°C from date of receipt.

Analysis Note

Evaluated by Western Blotting in human serum.

Western Blotting Analysis: A 1:1,000 dilution of this antibody detected Alpha-2-HS-Glycoprotein in human serum.

Other Notes

Concentration: Please refer to lot specific datasheet.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Anti-Alpha-2-HS-Glycoprotein from rabbit, purified by affinity chromatography

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description

from rabbit, purified by affinity chromatography

description

clone FetA-M, purified from hybridoma cell culture

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

description

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody form

purified from hybridoma cell culture

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

biological source

rabbit

biological source

mouse

biological source

rabbit

biological source

rabbit

technique(s)

western blot: suitable, immunohistochemistry: suitable

technique(s)

immunoblotting: 2-4 μg/mL using Human serum

technique(s)

immunohistochemistry: 1:50-1:200, immunofluorescence: 0.25-2 μg/mL, immunoblotting: 0.04-0.4 μg/mL

technique(s)

western blot: 0.04-0.4 μg/mL, immunohistochemistry: 1:200-1:500, immunofluorescence: 0.25-2 μg/mL

Gene Information

human ... AHSG(197)

Gene Information

human ... AHSG(197)

Gene Information

human ... AHSG(197)

Gene Information

human ... AHSG(197)

UniProt accession no.

P02765

UniProt accession no.

P02765

UniProt accession no.

P02765

UniProt accession no.

P02765

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