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27102

Citric acid monohydrate

puriss., meets analytical specification of Ph. Eur., BP, USP, E330, 99.5-100.5% (based on anhydrous substance), grit

Synonym(s):

2-hydroxy-1,2,3-propanetricarboxylic acid monohydrate

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About This Item

Linear Formula:
HOC(COOH)(CH2COOH)2 · H2O
CAS Number:
Molecular Weight:
210.14
UNSPSC Code:
12352100
NACRES:
NA.21
PubChem Substance ID:
EC Number:
201-069-1
Beilstein/REAXYS Number:
4018641
MDL number:
Assay:
99.5-100.5% (based on anhydrous substance)
Form:
grit
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grade

puriss.

Quality Segment

assay

99.5-100.5% (based on anhydrous substance)

form

grit

quality

meets analytical specification of Ph. Eur., BP, USP, E330

impurities

residual solvents, complies, ≤0.0005% heavy metals (as Pb), 7.5-8.8% water (Karl Fischer)

ign. residue

≤0.05% (as SO4)

pKa 

(1) 3.13, (2) 4.76, (3) 6.4

anion traces

chloride (Cl-): ≤50 mg/kg, oxalate (as oxalic acid): ≤100 mg/kg, sulfate (SO42-): ≤100 mg/kg

cation traces

As: ≤1 mg/kg, Ca: ≤200 mg/kg, Cu: ≤10 mg/kg, Fe: ≤10 mg/kg, Hg: ≤1 mg/kg, Pb: ≤1 mg/kg, Zn: ≤10 mg/kg

suitability

complies for appearance of solution, complies for identity (IR), complies for reaction against H2SO4

functional group

carboxylic acid

SMILES string

OC(CC(O)(C(O)=O)CC(O)=O)=O.O

InChI

1S/C6H8O7.H2O/c7-3(8)1-6(13,5(11)12)2-4(9)10;/h13H,1-2H2,(H,7,8)(H,9,10)(H,11,12);1H2

InChI key

YASYEJJMZJALEJ-UHFFFAOYSA-N

General description

Citric acid monohydrate is an organic acid. Its molar enthalpy of solution in water has been reported to be ΔsolHm (298.15K, m = 0.0203molkg-1) = (29061 ± 123)Jmol-1

Application

Citric acid monohydrate may be used in the diltiazem hydrochloride (drug) and melt extruded Eudragit RS PO (polymer) formulations. It improves the solubility of drug in the polymer matrix. It may be used to prepare citrate buffer for use in the intravital microscopic studies of adhesion and aggregation of platelets.


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Pictograms

Exclamation mark

Signal Word

Warning

Hazard Codes

Hazard Classifications

Eye Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class

11 - Combustible Solids

Flash Point (°F)

345.0 °F - closed cup

Flash Point (°C)

173.9 °C - closed cup

PPE (personal protective equipment)

dust mask type N95 (US), Eyeshields, Gloves



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