IA00007
DMG-PEG 2000
ultrapure grade
Synonym(s):
1,2-Dimyristoyl-rac-glycero-3-methoxypolyethylene glycol-2000, mPEG-2kDa-DMG
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About This Item
Empirical Formula (Hill Notation):
C122H242O50
CAS Number:
Molecular Weight:
2509.20
NACRES:
NA.21
biological source
synthetic
Quality Segment
grade
ultrapure grade
assay
≥95% (,CAD, HPLC)
form
solid
packaging
pkg of 1 × 1 g (IA00007-1G)
application(s)
advanced drug delivery
lipid type
polymerizable lipids
shipped in
dry ice
storage temp.
−20°C
SMILES string
O=C(CCCCCCCCCCCCC)OCC(OC(CCCCCCCCCCCCC)=O)COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC
General description
DMG-PEG 2000, also known as dimyristoyl glycerophosphoethanolamine conjugated to polyethylene glycol 2000, is commonly used as a reagent to modify and functionalize biomolecules. It is often utilized to improve the solubility, stability, and pharmacokinetic properties of conjugated biomolecules, making it valuable in drug delivery, diagnostics, and biotechnology research.
Application
- mRNA vaccine and therapeutic LNP formulation
- siRNA and antisense oligonucleotide (ASO) delivery systems
- Gene editing platform development (CRISPR/Cas9 and base editing)
- Oncology and rare disease nucleic acid therapeutic research and development
Features and Benefits
- Hydrophilic PEG2000 corona provides robust steric stabilization of LNP surfaceModulates
- LNP particle size and polydispersity index (PDI) during formulation
- Reduces opsonization and non-specific immune recognition in systemic circulation
- Efficient intracellular delivery
- DMG PEG2000 has broad compatibility with ionizable lipids, helper lipids, and cholesterol in standard LNP systems
- It is extensively characterized and referenced across preclinical and clinical LNP literature
- Research grade products that can easily be scaled to meets GMP needs.
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Flash Point (°C)
Not applicable
Storage Class
11 - Combustible Solids
Flash Point (°F)
Not applicable
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