Key Documents

Zopiclone

Name: Zopiclone
Brand: SIAL
Price: 131 EUR

European Pharmacopoeia (EP) Reference Standard

Synonym(s):

4-Methyl-1-piperazinecarboxylic acid 6-(5-chloro-2-pyridinyl)-6,7-dihydro-7-oxo-5H-pyrrolo[3,4-b]pyrazin-5-yl ester, Imovane

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Pack Size	SKU	Availability	Price
40 mg		Please contact Customer Service for Availability	€131.00

About This Item

Empirical Formula (Hill Notation):

C₁₇H₁₇ClN₆O₃

CAS Number:

43200-80-2

Molecular Weight:

388.81

NACRES:

NA.24

PubChem Substance ID:

329831609

UNSPSC Code:

41116107

MDL number:

MFCD00133931

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Properties

grade

pharmaceutical primary standard

API family

zopiclone

manufacturer/tradename

EDQM

application(s)

pharmaceutical (small molecule)

format

neat

storage temp.

2-8°C

SMILES string

CN1CCN(CC1)C(=O)OC2N(C(=O)c3nccnc23)c4ccc(Cl)cn4

InChI

1S/C17H17ClN6O3/c1-22-6-8-23(9-7-22)17(26)27-16-14-13(19-4-5-20-14)15(25)24(16)12-3-2-11(18)10-21-12/h2-5,10,16H,6-9H2,1H3

InChI key

GBBSUAFBMRNDJC-UHFFFAOYSA-N

Description

General description

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Zopiclone EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Packaging

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Other Notes

Sales restrictions may apply.

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1 of 1

This Item	BP812	Z3001000	Y0001822
Z3000000 Zopiclone	BP812 Zopiclone	Z3001000 Zopiclone oxide	Y0001822 Zopiclone impurity B
manufacturer/tradename EDQM	manufacturer/tradename BP	manufacturer/tradename EDQM	manufacturer/tradename EDQM
grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard	grade pharmaceutical primary standard
application(s) pharmaceutical (small molecule)	application(s) pharmaceutical pharmaceutical small molecule	application(s) pharmaceutical (small molecule)	application(s) pharmaceutical (small molecule)
format neat	format neat	format neat	format neat
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
API family zopiclone	API family zopiclone	API family zopiclone	API family zopiclone

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pictograms

GHS08,GHS07,GHS09

signalword

Warning

hcodes

H302,H336,H361fd,H411

pcodes

P202 - P261 - P264 - P273 - P301 + P312 - P308 + P313

Hazard Classifications

Acute Tox. 4 Oral - Aquatic Chronic 2 - Repr. 2 - STOT SE 3

target_organs

Central nervous system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

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Zopiclone, the third generation hypnotic: a clinical overview.

B Musch et al.

International clinical psychopharmacology, 5 Suppl 2, 147-158 (1990-04-01)

Effective and safe hypnotics exist especially since the introduction of benzodiazepines (BZD) which appeared to bring major advantages over barbiturates. Ideally a new hypnotic should induce and maintain sleep without producing residual effect during the day and should be devoid

A comparative assessment of the risks and benefits of zopiclone: a review of 15 years' clinical experience.

G Hajak

Drug safety, 21(6), 457-469 (1999-12-28)

Zopiclone is a cyclopyrrolone hypnosedative that is chemically unrelated to the benzodiazepines but nevertheless potentiates gamma-aminobutyric acid-mediated neuronal inhibition, and has demonstrated proven efficacy and good tolerability in the treatment of insomnia over 15 years of use. Zopiclone is indicated

Zopiclone as positive control in studies examining the residual effects of hypnotic drugs on driving ability.

Joris C Verster et al.

Current drug safety, 6(4), 209-218 (2011-12-02)

Zopiclone (7.5 mg) is frequently used as a positive control in studies that examine the residual effects of hypnotic drugs on driving ability and related skills. This review summarizes studies examining the effects of zopiclone, and discusses its usefulness as

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Global Trade Item Number

SKU	GTIN
Z3000000	04061833798157

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