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56690

Hypericin from Hypericum perforatum

~95% (HPLC)

Synonyme(s) :

4,5,7,4′,5′,7′-Hexahydroxy-2,2′-dimethylnaphthodianthrone, Cyclo werrol, Hypericum red

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A propos de cet article

Formule empirique (notation de Hill) :
C30H16O8
Numéro CAS:
Poids moléculaire :
504.44
NACRES:
NA.77
PubChem Substance ID:
EC Number:
208-941-0
Beilstein/REAXYS Number:
1917913
MDL number:
UNSPSC Code:
51101500


assay

~95% (HPLC)

solubility

1 M NaOH: 10 mg/mL, turbid, dark green

SMILES string

Cc1cc(O)c2C(=O)c3c(O)cc(O)c4c5c(O)cc(O)c6C(=O)c7c(O)cc(C)c8c1c2c(c34)c(c78)c56

InChI

1S/C30H16O8/c1-7-3-9(31)19-23-15(7)16-8(2)4-10(32)20-24(16)28-26-18(12(34)6-14(36)22(26)30(20)38)17-11(33)5-13(35)21(29(19)37)25(17)27(23)28/h3-6,31-36H,1-2H3

InChI key

BTXNYTINYBABQR-UHFFFAOYSA-N

General description

Hypericin hydrophobic is a red color pigment occurring naturally in Hypericum perforatum. Its fluorescence is measured at 600 nm.[1] It is localized in the intracellular membranes including nuclear membrane, mitochondrial membrane, Golgi apparatus, lysosomes and endoplasmic reticulum.

Application

Hypericin from Hypericum perforatum has been used:
  • in the broth macrodilution test and antibacterial assay against bacterial strains
  • as a medium supplement for human malignant melanoma cells for irradiation and localization studies
  • as a ligand for pregnane X receptor (PXR) and as defatting medium supplement for primary human hepatocytes culture

Biochem/physiol Actions

Anthraquinone-derivative within St. John′s wort. Antibacterial effective against Gram-positive and Gram-negative bacteria.
Hypericin is a potent inhibitor of protein kinase C (PKC), telomerase, cytochrome P450 and reverse transcriptase.[1] It is exploited for its photosensitizing functionality in photodynamic therapy (PDT) and photodynamic diagnosis (PDD) in cancer cells.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

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Cet article
PHL89226400076-M00190585
Hypericin phyproof® Reference Substance

PHL89226

Hypericin

Hypericin primary reference standard

00190585

Hypericin

description

~95% (HPLC)

description

phyproof® Reference Substance

description

Polycyclic dione that has anti-retroviral activity.

description

primary reference standard

assay

~95% (HPLC)

assay

≥95.0% (HPLC)

assay

≥98% (HPLC)

assay

-

solubility

1 M NaOH: 10 mg/mL, turbid, dark green

solubility

-

solubility

ethanol: 1 mg/mL, methanol: 1 mg/mL, DMSO: 10 mg/mL

solubility

-


pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Classe de stockage

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves



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