C8541
Monoclonal Anti-Cytokeratin Peptide 18 antibody produced in mouse
clone CY-90, ascites fluid
Synonym(s):
Monoclonal Anti-Cytokeratin Peptide 18
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 μL | Check Cart for Availability | $607.00 $515.95 | |
| 0.2 mL | Check Cart for Availability | $727.00 $617.95 |
About This Item
Conjugate:
unconjugated
Clone:
CY-90, monoclonal
Application:
IF, WB
Citations:
32
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
CY-90, monoclonal
contains
15 mM sodium azide
species reactivity
wide range
technique(s)
indirect immunofluorescence: 1:800 using formalin-fixed, paraffin-embedded sections of human tissue, western blot: suitable
isotype
IgG1
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... KRT18(3875)
General description
Cytokeratin 18 (45 kDa) is the primary type I keratin expressed in simple epithelial cells. Epithelial cells and their derivatives characteristically contain intermediate filaments (IFs) composed of about 20 related polypeptides with molecular weights between 40,000-69,000. Each epithelial tissue has a specific and stable pattern of expression of some of these cytokeratin subunits. Epithelium derived tumors maintain the expression of the cytokeratins found in the normal tissue of origin. Therefore, carcinomas can be identified and classified by immunocytochemical staining with antibodies that react specifically with cytokeratins.
Monoclonal Anti-Cytokeratin Peptide 18 (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Cytokeratin 18 (CK18)/keratin 18 is a structural protein and is present in single-layer epithelia. It is located on human chromosome 12q13.
Immunogen
human epidermal carcinoma A-431 and MCF-7 human breast cancer cell lines.
Application
Monoclonal Anti-Cytokeratin Peptide 18 antibody produced in mouse has been used in:
- immunofluorescence
- fluorescence microscopy
- confocal fluorescence microscopy
- immunolabelling
- histoblots
Biochem/physiol Actions
Keratins help to maintain structural integrity. They also control Fas?mediated apoptosis and regulate cell size and protein synthesis. Cytokeratin 18 (CK18) plays a major role in the development of lung cancer. It acts as a therapeutic target for non-small cell lung cancer (NSCLC). CK-18 is considered as a promising plasma biomarker to identify patients with HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome.
The antibody reacts specifically with a wide variety of simple epithelia (e.g. intestine, respiratory and urinary systems, liver, and glandular epithelia). It does not react with stratified squamous epithelia (e.g. esophagus or epidermis) or with non-epithelial cells.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
1 of 1
This Item | |||
|---|---|---|---|
| Gene Information human ... KRT18(3875) | Gene Information human ... KRT18(3875) | Gene Information - | Gene Information human ... KRT18(3875) |
| biological source mouse | biological source mouse | biological source - | biological source mouse |
| clone CY-90, monoclonal | clone KS-B17.2, monoclonal | clone CY-90, monoclonal | clone CY-90, monoclonal |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate FITC conjugate |
| species reactivity wide range | species reactivity human | species reactivity human | species reactivity wide range |
| antibody form ascites fluid | antibody form ascites fluid | antibody form purified from hybridoma cell culture | antibody form purified immunoglobulin |
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Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| C8541-.2ML | 04061838104564 |
| C8541-100UL | 04061838030511 |