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C8541

Monoclonal Anti-Cytokeratin Peptide 18 antibody produced in mouse

clone CY-90, ascites fluid

Synonym(s):

Monoclonal Anti-Cytokeratin Peptide 18

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100 μL
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$853.00
0.2 mL
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$1,020.00
$867.00

About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD00162250
Conjugate:
unconjugated
Clone:
CY-90, monoclonal
Application:
IF, WB
Citations:
32

$853.00

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biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

CY-90, monoclonal

contains

15 mM sodium azide

species reactivity

wide range

technique(s)

indirect immunofluorescence: 1:800 using formalin-fixed, paraffin-embedded sections of human tissue, western blot: suitable

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... KRT18(3875)

General description

Cytokeratin 18 (45 kDa) is the primary type I keratin expressed in simple epithelial cells. Epithelial cells and their derivatives characteristically contain intermediate filaments (IFs) composed of about 20 related polypeptides with molecular weights between 40,000-69,000. Each epithelial tissue has a specific and stable pattern of expression of some of these cytokeratin subunits. Epithelium derived tumors maintain the expression of the cytokeratins found in the normal tissue of origin. Therefore, carcinomas can be identified and classified by immunocytochemical staining with antibodies that react specifically with cytokeratins.
Monoclonal Anti-Cytokeratin Peptide 18 (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. Cytokeratin 18 (CK18)/keratin 18 is a structural protein and is present in single-layer epithelia. It is located on human chromosome 12q13.

Immunogen

human epidermal carcinoma A-431 and MCF-7 human breast cancer cell lines.

Application

Monoclonal Anti-Cytokeratin Peptide 18 antibody produced in mouse has been used in:
  • immunofluorescence
  • fluorescence microscopy
  • confocal fluorescence microscopy
  • immunolabelling
  • histoblots

Biochem/physiol Actions

Keratins help to maintain structural integrity. They also control Fas?mediated apoptosis and regulate cell size and protein synthesis. Cytokeratin 18 (CK18) plays a major role in the development of lung cancer. It acts as a therapeutic target for non-small cell lung cancer (NSCLC). CK-18 is considered as a promising plasma biomarker to identify patients with HELLP (hemolysis, elevated liver enzymes, low platelets) syndrome.
The antibody reacts specifically with a wide variety of simple epithelia (e.g. intestine, respiratory and urinary systems, liver, and glandular epithelia). It does not react with stratified squamous epithelia (e.g. esophagus or epidermis) or with non-epithelial cells.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Anti-Cytokeratin Peptide 18 antibody, Mouse monoclonal clone KS-B17.2, purified from hybridoma cell culture

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Anti-Cytokeratin Peptide 18 antibody, Mouse monoclonal

Anti-Cytokeratin Peptide 18 antibody, Mouse monoclonal clone KS-B17.2, purified from hybridoma cell culture

Sigma-Aldrich

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Anti-Cytokeratin Peptide 18 antibody, Mouse monoclonal

biological source

mouse

biological source

mouse

biological source

mouse

biological source

mouse

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

Gene Information

human ... KRT18(3875)

Gene Information

human ... KRT18(3875)

Gene Information

human ... KRT18(3875)

Gene Information

human ... KRT18(3875)

species reactivity

wide range

species reactivity

human

species reactivity

human

species reactivity

human

antibody form

ascites fluid

antibody form

ascites fluid

antibody form

ascites fluid

antibody form

ascites fluid

clone

CY-90, monoclonal

clone

KS-B17.2, monoclonal

clone

KS-B17.2, monoclonal

clone

KS-B17.2, monoclonal

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Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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