Anti-VDAC3 antibody produced in rabbit

Voltage dependent anion channel 3 (VDAC3) is encoded by the gene mapped to human chromosome 8p11.2. The protein is predominantly expressed in testis. The protein consists of disulfide bridges with cysteine residues present on the barrel and exposed to the mitochondrial inter-membrane space.

Voltage-dependent anion-selective channel protein 3 recombinant protein epitope signature tag (PrEST)

Anti-VDAC3 antibody produced in rabbit has been used in western blotting. All Prestige Antibodies^®Powered by Atlas Antibodies is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

The human voltage dependent anion channel 3 (VDAC3) might be involved in the metabolism of cholesterol for steroidogenesis. VDAC3 functions as a pore-forming protein and regulates metabolite flux between mitochondria and cytoplasm. Channel gating of VDAC3 can be regulated via redox sensing under physiological conditions. In male mice, loss of VDAC3 leads to infertility. VDAC3 present at the maternal centriole controls centriole assembly by linking Mps1 to the centrosome.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

Corresponding Antigen APREST86796.

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

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