Skip to Content
MilliporeSigma

Key Documents

View All Documentation

L5170

Leukotriene A4 Hydrolase human

recombinant, expressed in E. coli

Synonym(s):

LTA-4 hydrolase, LTA4, LTA4H

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

CAS Number:
90119-07-6
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
3.3.2.6 (BRENDA, IUBMB)
MDL number:
MFCD08460576
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

recombinant

expressed in E. coli

description

contains C-terminal his-tag

assay

≥90% (SDS-PAGE)

mol wt

~69 kDa

NCBI accession no.

shipped in

dry ice

storage temp.

−70°C

Gene Information

human ... LTA4H(4048)

Application

Leukotriene A4 Hydrolase human (LTA4H) is a drug target for anti-inflammation, and for cancer prevention and therapy. It is also suitable for screening inhibitors of Leukotriene B4 synthesis. LTA4H is used to study allergic asthma and airway hyperresponsiveness .

Biochem/physiol Actions

Leukotriene A4 Hydrolase human (LTA4H) is a bifunctional zinc metalloenzyme that converts LTA4 into Leukotriene B4, and also demonstrates aminopeptidase activity. Leukotriene B4 is a lipid chemoattractant that plays critical roles in inflammaton, immune responses, host defenses against infections, and lipid homeostasis. Inhibition of LTA4H in a mouse model decreases LTB4 in the airways and attenuates airway inflammation and airway hyperreactivity through modulation of T cell and dendritic cell function .

Physical form

Supplied as a solution in 100mM Tris, pH 8.0, containing 20% glycerol and 100mM potassium chloride.

Storage Class

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library