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Monoclonal Anti-Myocardin antibody produced in mouse

Name: Monoclonal Anti-Myocardin antibody produced in mouse
Brand: SIGMA

~2.0 mg/mL, clone MCR54, purified immunoglobulin

Synonym(s):

Anti-MYCD, Anti-MYOCD

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

MCR54, monoclonal

Application:

Citations:

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Properties

biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

MCR54, monoclonal

form

buffered aqueous solution

mol wt

antigen ~150 kDa

species reactivity

human

packaging

antibody small pack of 25 μL

concentration

~2.0 mg/mL

technique(s)

western blot: 2.5-5 μg/mL using HEK-293T cells overexpressing myocardin

isotype

IgG2b

UniProt accession no.

Q8IZQ8

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... MYOCD(93649)

Description

General description

Monoclonal Anti-Myocardin (mouse IgG2b isotype) is derived from the hybridoma MCR54 produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a synthetic peptide corresponding to a fragment of human myocardin. Myocardin (MYOCD) is a transcriptional coactivator.

Myocardin (MYOCD) is expressed in the muscles and cardiomyocytes. It is a co-transcriptional factor.[1]

Application

Monoclonal Anti-Myocardin antibody produced in mouse has been used in western blot analysisimmunofluorescence.

Biochem/physiol Actions

Myocardin (MYOCD) takes part in the differentiation of vascular smooth muscle cells (VSMC). It is a co-factor of serum response factor (SRF) and regulates the activation of those genes which are dependent on SRF. MYOCD forms a complex with SRF on DNA.[1]

Myocardin is a smooth and cardiac muscle-specific transcriptional coactivator of serum response factor (SRF). It regulates the expression of a set of cardiac and smooth muscle-specific genes. Myocardin was implicated in the pathogenesis of atherosclerosis, Alzheimer′s disease, and malignant transformation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Show Differences

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This Item	SAB4200539	SAB4200317	SAB4200598
Sigma-Aldrich M8948 Monoclonal Anti-Myocardin antibody produced in mouse	Sigma-Aldrich SAB4200539 Anti-Myocardin antibody produced in rabbit	Sigma-Aldrich SAB4200317 Anti-OS9 antibody, Mouse monoclonal	Sigma-Aldrich SAB4200598 Monoclonal Anti-FTH1 antibody produced in mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin
Gene Information human ... MYOCD(93649)	Gene Information human ... MYOCD(93649) mouse ... Myocd(214384) rat ... Myocd(246297)	Gene Information human ... OS9(10956) mouse ... Os9(216440) rat ... Os9(362891)	Gene Information human ... FTH1(2495)
biological source mouse	biological source rabbit	biological source mouse	biological source mouse
species reactivity human	species reactivity rat, human, mouse	species reactivity human, rat, mouse	species reactivity human
clone MCR54, monoclonal	clone polyclonal	clone OS9-8, monoclonal	clone FTH24, monoclonal

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Storage Class

12 - Non Combustible Liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

020M4772

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Global Trade Item Number

SKU	GTIN
M8948-25UL	04061837794865
M8948-200UL	04061837794858

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