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P0072

Anti-phospho-PDCD4 (pSer67) antibody produced in rabbit

~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Sinónimos:

Anti-Neoplastic transformation inhibitor, Anti-Nuclear antigen H731, Anti-Programmed cell death 4, Anti-Protein 197/15a

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NACRES:
NA.41
UNSPSC Code:
12352203
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IP, WB
Citations:
5
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biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~51 kDa

species reactivity

rat (predicted), mouse (predicted), human

concentration

~1 mg/mL

technique(s)

immunoprecipitation (IP): 5-10 μg using lysates of HEK-293T cells starved for 48 hours and then treated with 20% FCS, western blot: 1-2 μg/mL using lystes of HEK-293T cells starved for 48 hours and then treated with 20% FCS

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Este artículo
P0071SAB1410539HPA001032
Anti-phospho-PDCD4 (pSer67) antibody produced in rabbit ~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

P0072

Anti-phospho-PDCD4 (pSer67) antibody produced in rabbit

Anti-PDCD4 antibody produced in rabbit ~1 mg/mL, affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

P0071

Anti-PDCD4 antibody produced in rabbit

Anti-PDCD4 antibody produced in rabbit purified immunoglobulin, buffered aqueous solution

Sigma-Aldrich

SAB1410539

Anti-PDCD4 antibody produced in rabbit

Anti-PDCD4 antibody produced in rabbit Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Sigma-Aldrich

HPA001032

Anti-PDCD4 antibody produced in rabbit

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

antibody form

affinity isolated antibody

biological source

rabbit

biological source

rabbit

biological source

rabbit

biological source

rabbit

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

mol wt

antigen ~51 kDa

mol wt

antigen ~51 kDa

mol wt

antigen 51.8 kDa

mol wt

-

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

polyclonal

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous solution

form

buffered aqueous glycerol solution

General description

Programmed cell death 4 (PDCD4) also known as nuclear antigen H731-like, Protein 197/15a, neoplastic transformation inhibitor protein), is a tumor suppressor protein that is lost in progressed carcinomas of lung, breast, colon and prostate.

Application

Anti-phospho-PDCD4 (pSer67) antibody produced in rabbit has been used in immunoblotting.

Biochem/physiol Actions

Programmed cell death 4 (PDCD4) suppresses translation initiation by specifically inhibiting the helicase activity of eukaryotic translation initiation factor 4A (eIF4A), a component of the translation initiation complex and by competing with eIF4G, a second component of the translation initiation complex, for binding to eIF4A. In response to mitogens, PDCD4 was rapidly phosphorylated on Ser67 by the protein kinase S6K1 and subsequently degraded via the ubiquitin ligase SCF-β (TRCP). It has been shown that the protein is specifically phosphorylated on Ser67 and Ser457 by Akt, both in vitro and in vivo. This phosphorylation causes nuclear translocation of PDCD4.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Clase de almacenamiento

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificados de análisis (COA)

Lot/Batch Number
108K4766

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Programmed cell death protein 4 suppresses CDK1/cdc2 via induction of p21Waf1/Cip1
Goke R, et al.
American Journal of Physiology. Cell Physiology, C1541-C1546 (2004)
Programmed Cell Death 4 (PDCD4): A Novel Player in Ethanol Mediated Suppression of Protein Translation in Primary Cortical Neurons and Developing Cerebral Cortex
Narasimhan M, et al.
Alcoholism, Clinical and Experimental Research, 37(1), 96-96 (2013)
S6K1- and betaTRCP-mediated degradation of PDCD4 promotes protein translation and cell growth
Dorrello NV, et al.
Science (New York, N.Y.), 314(5798), 467-471 (2006)
Cory M Howard et al.
Frontiers in oncology, 9, 284-284 (2019-05-21)
Triple-negative breast cancer (TNBC) remains clinically challenging as effective targeted therapies are lacking. In addition, patient mortality mainly results from the metastasized lesions. CXCR4 has been identified to be one of the major chemokine receptors involved in breast cancer metastasis.
Jesse J Chen et al.
The Journal of biological chemistry, 286(47), 40867-40877 (2011-10-05)
Ubiquitin-activating enzyme (UAE or E1) activates ubiquitin via an adenylate intermediate and catalyzes its transfer to a ubiquitin-conjugating enzyme (E2). MLN4924 is an adenosine sulfamate analogue that was identified as a selective, mechanism-based inhibitor of NEDD8-activating enzyme (NAE), another E1

Contenido relacionado

Data Sheet - P0072

Instructions

Número de artículo de comercio global

SKUGTIN
P0072-200UL04061838173515

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