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R3779

Anti-RbAp48/RbAp46 antibody produced in rabbit

Name: Anti-RbAp48/RbAp46 antibody produced in rabbit
Brand: SIGMA

IgG fraction of antiserum, buffered aqueous solution

Synonym(e):

Anti-Retinoblastoma-binding protein

zur Ansicht der Organisations- und Vertragspreise.

Über diesen Artikel

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02686588

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, IF, WB

Citations:

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Eigenschaften

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 46 kDa (RbAp46), antigen 48 kDa (RbAp48)

species reactivity

human

technique(s)

indirect immunofluorescence: 1:500-1:1,000 using human HeLa cells fixed with paraformaldehyde-Triton, microarray: suitable, western blot: 1:2,000-1:4,000 using MCF7 nuclear extracts

UniProt accession no.

Q16576

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RBBP4(5928), RBBP7(5931)
mouse ... Rbbp4(19646), Rbbp7(245688)
rat ... Rbbp4(313048), Rbbp7(83712)

Beschreibung

General description

pRB-associated proteins p48 (RbAp48) is a 425 amino acids WD-domain protein isolated as a RB1 (retinoblastoma binding protein). RbAp46 (also known as RBBP7- retinoblastoma-binding protein 7) has 89% amino acid identity with RbAp48.

Immunogen

synthetic peptide corresponding to amino acids 413-425 of human RbAp48, conjugated to KLH via an N-terminal added lysine residue. The immunizing peptide is conserved in human, mouse, and rat.

Application

Anti-RbAp48/RbAp46 antibody produced in rabbit has been used in immunoblotting and immunofluorescence.

Biochem/physiol Actions

RbAp46 and RbAp48 are two histone tail-targeting proteins, that are found in association with chromatin remodeling complexes Sin3A/ histone deacetylase (HDAC) and NURD (nucleosomal remodeling and deacetylation complex). Transcriptional repressors exert their effects by recruitment of the Sin3A/HDAC corepressor complex, which contains a module composed of Sin3A, HDAC1, HDAC2, RbAp46, RbAp48, SAP30, and others. In the NuRD complex, HDAC1, HDAC2, RbAp48, and RbAp46 associate with MTA2 (metastasis associated 1 family member 2), MBD3 (methyl-CpG binding domain protein), MAT1L1, MBD3L1 (methyl-CpG binding domain protein 3 like 1), CHD3, and CHD4 to form the nucleosomal remodeling and deacetylation (NuRD) complex.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Dieser Artikel	SAB3500491	WH0005930M1	HPA060710
$Anti-RbAp48/RbAp46 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich R3779 Anti-RbAp48/RbAp46 antibody produced in rabbit	Sigma-Aldrich SAB3500491 Anti-RBBP8 antibody produced in rabbit	Sigma-Aldrich WH0005930M1 Monoclonal Anti-RBBP6 antibody produced in mouse	Sigma-Aldrich HPA060710 Anti-RBBP4 antibody produced in rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source rabbit	biological source mouse	biological source rabbit
antibody form IgG fraction of antiserum	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form affinity isolated antibody
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous glycerol solution
Gene Information human ... RBBP4(5928), RBBP7(5931) mouse ... Rbbp4(19646), Rbbp7(245688) rat ... Rbbp4(313048), Rbbp7(83712)	Gene Information human ... RBBP8(5932)	Gene Information human ... RBBP6(5930)	Gene Information human ... RBBP4(5928)
shipped in dry ice	shipped in dry ice	shipped in dry ice	shipped in wet ice

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wgk

WGK 3

Lagerklasse

10 - Combustible liquids

flash_point_f

Not applicable

flash_point_c