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A0885

Aurintricarboxylic acid ammonium salt

powder

Synonym(s):

ATA, Aluminon, Ammonium aurintricarboxylate

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Pack SizeSKUAvailabilityPrice
25 g
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$101.00

About This Item

Linear Formula:
C22H14O9 · 3NH3
CAS Number:
569-58-4
Molecular Weight:
473.43
EC Number:
209-319-1
UNSPSC Code:
12171500
NACRES:
NA.47
PubChem Substance ID:
24890465
MDL number:
MFCD00040925
Colour Index Number:
43810
Beilstein/REAXYS Number:
3900820

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biological source

synthetic

Quality Level

200

form

powder

color

dark red

mp

220-225 °C (dec.) (lit.)

solubility

water: soluble 100 mg/mL, dark red

λmax

552 nm (λmax: )

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

N.N.N.OC(=O)c1cc(ccc1O)\C(c2ccc(O)c(c2)C(O)=O)=C3/C=CC(=O)C(=C3)C(O)=O

InChI

1S/C22H14O9.3H3N/c23-16-4-1-10(7-13(16)20(26)27)19(11-2-5-17(24)14(8-11)21(28)29)12-3-6-18(25)15(9-12)22(30)31;;;/h1-9,23-24H,(H,26,27)(H,28,29)(H,30,31);3*1H3

InChI key

AIPNSHNRCQOTRI-UHFFFAOYSA-N

Application

Aurintricarboxylic acid ammonium salt has been used as a nuclease inhibitor to study its effects on transfection.

Biochem/physiol Actions

Aurintricarboxylic acid readily polymerizes in aqueous solution, forming a stable free radical that inhibits protein-nucleic acid interactions. It is a potent inhibitor of ribonuclease and topoisomerase II by preventing the binding of the nucleic acid to the enzyme. It stimulates tyrosine phosphorylation processes including the Jak2/STAT5 pathway in NB2 lymphoma cells, ErbB4 in neuroblastoma cells, and MAP kinases, Shc proteins, phosphatidylinositide 3-kinase and phospholipase C in PC12 cells. Aurintricarboxylic acid inhibits apoptosis in many cell types. Its neuroprotective effect, perhaps due to its ability to prevent down-regulation of Ca2+ impermeable GluR2 receptors or to its ability to inhibit calpain, a Ca2+-activated protease that is activated during apoptosis.

Other Notes

May contain a substantial amount of polymeric material.

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This Item
A36883A189501-3110
Aurintricarboxylic acid ammonium salt powder

Sigma-Aldrich

A0885

Aurintricarboxylic acid ammonium salt

Aurintricarboxylic acid ammonium salt ACS reagent

Sigma-Aldrich

A36883

Aurintricarboxylic acid ammonium salt

Aurintricarboxylic acid practical grade, ≥85% (titration), powder

Sigma-Aldrich

A1895

Aurintricarboxylic acid

Aluminon JIS special grade

Sigma-Aldrich

01-3110

Aluminon

color

dark red

color

dark red

color

red to very dark red, and Red-Brown andBrown-Red

color

-

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

diagnostic assay manufacturing
hematology
histology

application(s)

-

form

powder

form

powder or crystals

form

powder

form

powder

solubility

water: soluble 100 mg/mL, dark red

solubility

water: soluble 100 mg/mL

solubility

1 M NH4OH: 10 mg/mL

solubility

water: soluble

Quality Level

200

Quality Level

300

Quality Level

300

Quality Level

-

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

storage temp.

room temp

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Storage Class

11 - Combustible Solids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN2616
0000371776
0000371776
BCCM5298
0000263232

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Efficient nonviral cutaneous transfection
Glasspool-Malone et al.
Molecular Therapy, 140-146 (2000)
Moonhee Lee et al.
Neurobiology of aging, 33(10), 2237-2246 (2012-01-06)
Complement plays a vital role in both the innate and adaptive immune systems. It recognizes a target, opsonizes it, generates anaphylatoxins, and directly kills cells through the membrane attack complex (MAC). This final function, which assembles C5b-9(n) on viable cell
Qiang Peng et al.
PloS one, 7(10), e47273-e47273 (2012-11-03)
Baboons receiving xenogeneic livers from wild type and transgenic pigs survive less than 10 days. One of the major issues is the early development of profound thrombocytopenia that results in fatal hemorrhage. Histological examination of xenotransplanted livers has shown baboon
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Global Trade Item Number

SKUGTIN
A0885-25G04061833334560

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