A254
AIDA
solid
Synonym(s):
1-Amino-2,3-dihydro-1H-indene-1,5-dicarboxylic acid, 1-Aminoindan-1, 5-dicarboxylic acid, UPF 523
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About This Item
Empirical Formula (Hill Notation):
C11H11NO4
CAS Number:
Molecular Weight:
221.21
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
Form:
solid
Quality level:
Pricing and availability is not currently available.
form
solid
Quality Level
color
white
solubility
DMSO: 2 mg/mL
SMILES string
NC1(CCc2cc(ccc12)C(O)=O)C(O)=O
InChI
1S/C11H11NO4/c12-11(10(15)16)4-3-6-5-7(9(13)14)1-2-8(6)11/h1-2,5H,3-4,12H2,(H,13,14)(H,15,16)
InChI key
LSTPKMWNRWCNLS-UHFFFAOYSA-N
Gene Information
human ... GRM1(2911)
rat ... Grm1(24414)
Biochem/physiol Actions
Selective mGluR1 metabotropic glutamate receptor antagonist.
1 of 1
This Item | |||
|---|---|---|---|
| form solid | form powder | form powder | form (Powder, Film or Oil) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 100 |
| solubility DMSO: 2 mg/mL | solubility DMSO: >20 mg/mL | solubility DMSO: >5 mg/mL | solubility DMSO: ≥15 mg/mL |
| color white | color - | color white to off-white | color - |
| Gene Information human ... GRM1(2911) | Gene Information - | Gene Information - | Gene Information - |
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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F Moroni et al.
The Journal of pharmacology and experimental therapeutics, 281(2), 721-729 (1997-05-01)
We examined the pharmacological profile of 1-aminoindan-1,5-dicarboxylic acid (AIDA), a rigid (carboxyphenyl)glycine derivative acting on metabotropic glutamate receptors (mGluRs). In cells transfected with mGluR1a, AIDA competitively antagonized the stimulatory responses of glutamate and (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid [(1S,3R)-ACPD] on phosphoinositide hydrolysis (pA2
Andreas Schuster et al.
Journal of clinical medicine, 9(1) (2020-01-17)
Background: Right ventricular (RV) function is a known predictor of adverse events in heart failure and following acute myocardial infarction (AMI). While right atrial (RA) involvement is well characterized in pulmonary arterial hypertension, its relative contributions to adverse events following
Maria Joseph et al.
Molecular neurodegeneration, 12(1), 88-88 (2017-12-06)
The microtubule-associated protein Tau plays a role in neurodegeneration as well as neurogenesis. Previous work has shown that the expression of the pro-aggregant mutant Tau repeat domain causes strong aggregation and pronounced neuronal loss in the hippocampus whereas the anti-aggregant
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A254-5MG | 04061833022566 |
| A254-25MG | 04061833022559 |