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A263

ATPA

solid

Synonym(s):

(RS)-2-Amino-3-(3-hydroxy-5-tert-butylisoxazol-4-yl)propanoic acid

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About This Item

Empirical Formula (Hill Notation):
C10H16N2O4
CAS Number:
83654-14-2
Molecular Weight:
228.25
NACRES:
NA.77
PubChem Substance ID:
24277951
UNSPSC Code:
12352202
MDL number:
MFCD01860864
Form:
solid
Quality level:
100

form

solid

Quality Level

100

color

white

solubility

DMSO: 10 mg/mL, H2O: 2.5 mg/mL

SMILES string

CC(C)(C)c1onc(O)c1CC(N)C(O)=O

InChI

1S/C10H16N2O4/c1-10(2,3)7-5(8(13)12-16-7)4-6(11)9(14)15/h6H,4,11H2,1-3H3,(H,12,13)(H,14,15)

InChI key

PIXJURSCCVBKRF-UHFFFAOYSA-N

Gene Information

human ... GRIK1(2897)
rat ... Gria1(50592), Grik1(29559), Grin2a(24409)

Biochem/physiol Actions

Selective kainate receptor agonist.

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This Item
A6816A6566A9111
ATPA solid

Sigma-Aldrich

A263

ATPA

(±)-AMPA solid

Sigma-Aldrich

A6816

(±)-AMPA

2-Hydroxysaclofen ≥98% (TLC), solid

Sigma-Aldrich

A6566

2-Hydroxysaclofen

(±)-AMPA hydrobromide ≥98% (HPLC)

Sigma-Aldrich

A9111

(±)-AMPA hydrobromide

form

solid

form

solid

form

solid

form

powder

Quality Level

100

Quality Level

200

Quality Level

200

Quality Level

100

solubility

DMSO: 10 mg/mL, H2O: 2.5 mg/mL

solubility

H2O: 1 mg/mL (warm), 0.1 M HCl: 3.5 mg/mL, 0.1 M NaOH: 4.3 mg/mL, DMSO: 4.3 mg/mL, 1 M HCl: 50 mg/mL

solubility

H2O: 1 mg/mL, 0.1 M HCl: 1.2 mg/mL, methanol: 1.4 mg/mL, DMSO: 28 mg/mL, 0.1 M NaOH: 9.5 mg/mL

solubility

H2O: ≥10 mg/mL

color

white

color

white

color

white

color

off-white to light tan

Gene Information

human ... GRIK1(2897)
rat ... Gria1(50592), Grik1(29559), Grin2a(24409)

Gene Information

rat ... Gria1(50592), Gria2(29627), Gria3(29628), Gria4(29629), Grik1(29559), Grik2(54257), Grin2a(24409), Grm1(24414), Grm2(24415), Grm4(24417), Grm5(24418), Slc1a1(25550), Slc1a2(29482), Slc1a3(29483)

Gene Information

human ... GABBR1(2550), GABBR2(9568)

Gene Information

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ0867
MKCM8001
MKCK5318
MKBQ2887V
040M1167

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Xiaoye Liu et al.
Frontiers in cell and developmental biology, 8, 590-590 (2020-08-01)
Migration of neutrophils across endothelial barriers to capture and eliminate bacteria is served as the first line of innate immunity. Bacterial virulence factors damage endothelium to produce inflammatory cytokines interacts with neutrophils. However, the mechanisms that behind endothelial-neutrophil interaction impact
Mai Marie Nielsen et al.
Molecular pharmacology, 63(1), 19-25 (2002-12-19)
Only a few agonists exhibit selectivity between the AMPA and the kainate subtypes of the glutamate receptor. The most commonly used kainate receptor preferring agonist, (S)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid [(S)-ATPA], is an (R,S)-2-amino-3-(5-methyl-3-hydroxy-4-isoxazolyl)propionic acid (AMPA) derivative in which the methyl group at
S E Lauri et al.
Neuropharmacology, 41(8), 907-915 (2001-12-19)
The development of GluR5-selective kainate receptor ligands is helping to elucidate the functions of kainate receptors in the CNS. Here we have further characterised the actions of a GluR5 selective agonist, ATPA, and a GluR5 selective antagonist, LY382884, in the
View All Related Papers

Global Trade Item Number

SKUGTIN
A263-5MG04061832088600