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Anti-α_2A Adrenergic Receptor antibody produced in rabbit

Name: Anti-α<SUB>2A</SUB> Adrenergic Receptor antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01321639

Conjugate:

unconjugated

Clone:

polyclonal

Application:

IHC (p), WB

Citations:

Pricing and availability is not currently available.

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Properties

biological source

rabbit

Quality Segment

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~45 kDa

species reactivity

rat, human, mouse, pig

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1000, western blot: 1:500

UniProt accession no.

P08913

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADRA2A(150)
mouse ... Adra2a(11551)
rat ... Adra2a(25083)

Description

General description

Adrenergic receptors (ARs) belong to the 7-transmembrane domain G protein-coupled receptor superfamily that binds to the endogenous catecholamines, epinephrine and norepinephrine. α₂AR subtypes block adenylyl cyclase, suppress voltage-sensitive Ca²⁺ channels, and stimulate receptor dependent K⁺ channels. All of the α₂AR subtypes inhibit adenylyl cyclase through coupling to members of the G_i/G_o class of G proteins. They are an important component of the neural circuitry and modulate cardiovascular physiology. The physiological function of the α₂ARs in the kidney is to regulate Na⁺/H⁺ exchange.
Anti-α_2A adrenergic receptor detects rat and mouse α_2A adrenergic receptors by immunoblotting and immunohistochemistry. In immunoblotting, the antibody detects an approx. 45kDa band representing α_2Areceptors in tissues expressing this receptor subtype, although some non-specific bands have also been observed in certain cases.

Immunogen

synthetic peptide derived from amino acids 218-235 of human, mouse, rat, and pig α_2A adrenergic receptor. The immunogen sequence is found within the third intracellular loop of the α_2A adrenergic receptor subtype.

Application

Rabbit anti-α_2A adrenergic receptor antibody can be used for western blot (1:500) and immunohistochemistry (1:1000) applications.

Physical form

Solution in phosphate buffered saline, containing 1 mg/ml BSA and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB5201000	SAB5201012	SAB5200997
Sigma-Aldrich A271 Anti-α_2A Adrenergic Receptor antibody produced in rabbit	Sigma-Aldrich SAB5201000 Monoclonal Anti-Alpha 2C Adrenergic Receptor - Atto 594 antibody produced in mouse	Sigma-Aldrich SAB5201012 Monoclonal Anti-Alpha 2C Adrenergic Receptor - Rpe antibody produced in mouse	Sigma-Aldrich SAB5200997 Monoclonal Anti-Alpha 2C Adrenergic Receptor - Atto 390 antibody produced in mouse
conjugate unconjugated	conjugate Atto 594 conjugate	conjugate phycoerythrin (R-PE) conjugate	conjugate Atto 390 conjugate
antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form purified immunoglobulin
Quality Level 200	Quality Level 100	Quality Level 100	Quality Level 100
biological source rabbit	biological source mouse	biological source mouse	biological source mouse
technique(s) immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1000, western blot: 1:500	technique(s) immunocytochemistry: suitable, western blot: suitable	technique(s) immunocytochemistry: suitable, western blot: suitable	technique(s) immunocytochemistry: suitable, western blot: suitable
mol wt antigen ~45 kDa	mol wt antigen predicted mol wt 50 kDa	mol wt antigen predicted mol wt 50 kDa	mol wt antigen predicted mol wt 50 kDa

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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