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A271

Anti-α2A Adrenergic Receptor antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41
MDL number:
MFCD01321639
Conjugate:
unconjugated
Clone:
polyclonal
Application:
IHC (p), WB
Citations:
6

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~45 kDa

species reactivity

rat, human, mouse, pig

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): 1:1000, western blot: 1:500

UniProt accession no.

P08913

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ADRA2A(150)
mouse ... Adra2a(11551)
rat ... Adra2a(25083)

General description

Adrenergic receptors (ARs) belong to the 7-transmembrane domain G protein-coupled receptor superfamily that binds to the endogenous catecholamines, epinephrine and norepinephrine. α2AR subtypes block adenylyl cyclase, suppress voltage-sensitive Ca2+ channels, and stimulate receptor dependent K+ channels. All of the α2AR subtypes inhibit adenylyl cyclase through coupling to members of the Gi/Go class of G proteins. They are an important component of the neural circuitry and modulate cardiovascular physiology. The physiological function of the α2ARs in the kidney is to regulate Na+/H+ exchange.
Anti-α2A adrenergic receptor detects rat and mouse α2A adrenergic receptors by immunoblotting and immunohistochemistry. In immunoblotting, the antibody detects an approx. 45kDa band representing α2A receptors in tissues expressing this receptor subtype, although some non-specific bands have also been observed in certain cases.

Immunogen

synthetic peptide derived from amino acids 218-235 of human, mouse, rat, and pig α2A adrenergic receptor. The immunogen sequence is found within the third intracellular loop of the α2A adrenergic receptor subtype.

Application

Rabbit anti-α2A adrenergic receptor antibody can be used for western blot (1:500) and immunohistochemistry (1:1000) applications.

Physical form

Solution in phosphate buffered saline, containing 1 mg/ml BSA and 0.05% sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item
SAB4500548SAB2500033SAB5200998
Anti-α2A Adrenergic Receptor antibody produced in rabbit affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

A271

Anti-α2A Adrenergic Receptor antibody produced in rabbit

Anti-Adrenergic Receptor α-2A antibody produced in rabbit affinity isolated antibody

Sigma-Aldrich

SAB4500548

Anti-Adrenergic Receptor α-2A antibody produced in rabbit

Anti-ADRA2A antibody produced in goat affinity isolated antibody, buffered aqueous solution

Sigma-Aldrich

SAB2500033

Anti-ADRA2A antibody produced in goat

Monoclonal Anti-Alpha 2C Adrenergic Receptor - Atto 488 antibody produced in mouse clone S330A-80, purified immunoglobulin

Sigma-Aldrich

SAB5200998

Monoclonal Anti-Alpha 2C Adrenergic Receptor - Atto 488 antibody produced in mouse

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

affinity isolated antibody

antibody form

purified immunoglobulin

biological source

rabbit

biological source

rabbit

biological source

goat

biological source

mouse

conjugate

unconjugated

conjugate

unconjugated

conjugate

unconjugated

conjugate

Atto 488 conjugate

Quality Level

200

Quality Level

100

Quality Level

100

Quality Level

100

clone

polyclonal

clone

polyclonal

clone

polyclonal

clone

S330A-80, monoclonal

species reactivity

rat, human, mouse, pig

species reactivity

mouse, human, rat

species reactivity

mouse, canine, human, rat

species reactivity

mouse, human

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Storage Class

10 - Combustible liquids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000300773
0000300773
SLCG4566
SLCG4568
SLBX2641

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Related Content

Data Sheet - A271

Instructions

Wenli Mi et al.
Anesthesia and analgesia, 125(3), 1032-1041 (2017-05-26)
Combination drug therapy is commonly used to treat chronic pain conditions such as neuropathic pain, and antidepressant is often used together with opioid analgesics. While rewarding is an intrinsic property of opioid analgesics, it is unknown whether the use of
Elvira Ganic et al.
Cell reports, 14(8), 1991-2002 (2016-02-26)
Monoamine and acetylcholine neurotransmitters from the autonomic nervous system (ANS) regulate insulin secretion in pancreatic islets. The molecular mechanisms controlling neurotransmitter signaling in islet β cells and their impact on diabetes development are only partially understood. Using a glucose-intolerant, MafA-deficient
Olena Fedotkina et al.
Frontiers in neuroscience, 16, 858049-858049 (2022-05-24)
Persons with type 2 diabetes born in the regions of famine exposures have disproportionally elevated risk of vision-threatening proliferative diabetic retinopathy (PDR) in adulthood. However, the underlying mechanisms are not known. In the present study, we aimed to investigate the
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Global Trade Item Number

SKUGTIN
A271-100UL04061837829734

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