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A7356

Anti-Atg16L in Kaninchen hergestellte Antikörper

Name: Anti-Atg16L in Kaninchen hergestellte Antikörper
Brand: SIGMA

fractionated antiserum, buffered aqueous solution

Synonym(e):

Anti-APG16L, Anti-ATG16 autophagy related 16-like 1 (S. cerevisiae), Anti-ATG16L1

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Über diesen Artikel

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

polyclonal

Application:

Citations:

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Eigenschaften

biological source

rabbit

conjugate

unconjugated

antibody form

fractionated antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen ~70 kDa (several isonform bands)

species reactivity

rat, mouse, human

technique(s)

western blot: 1:500-1:1,000 using whole extracts of human A549 cells, rat PC12 cells, and HEK-293T cells expressing mouse Atg16l

UniProt accession no.

Q676U5

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... ATG16L1(55054)
mouse ... Atg16l1(77040)
rat ... Atg16l1(363278)

Beschreibung

General description

ATG16L is a component of a large protein complex that is critical for autophagy.

Autophagy-related 16-like 1 (ATG16L1) is an autophagy gene, that is expressed in the colon, small intestine, intestinal epithelial cells, leukocytes and spleen. Atg16L is expressed in different isoform patterns depending on the tissue.

Immunogen

synthetic peptide correspopnding to amino acids 2-15 of mouse Atg16l, conjugated to KLH via a C-terminal cysteine residue. The corresponding sequence is identical in rat and human.

Application

Anti-Atg16L antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Atg16L is involved in LC3 lipidation during the formation of autphagosomes. Studies have reported that Atg16L may also function as a mammalian Rab33 effector.

Autophagy-related 16-like 1 (ATG16L1) modulates host immune responses and is linked with several diseases, like cardiovascular disease (CVD). Atg16 multimeric complex plays an essential role in autophagy. Atg16L interacts with both Atg5 and additional Atg16L monomers. Together with Atg12-Atg5 conjugate, Atg16L associates with the autophagic isolation membrane for the duration of autophagosome formation.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Dieser Artikel	SAB1305644	A2981	HPA045444
$Anti-Atg16L in Kaninchen hergestellte Antikörper fractionated antiserum, buffered aqueous solution$ Sigma-Aldrich A7356 Anti-Atg16L in Kaninchen hergestellte Antikörper	Sigma-Aldrich SAB1305644 ANTI-ATG16L antibody produced in rabbit	$Anti-ATG4B in Kaninchen hergestellte Antikörper IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich A2981 Anti-ATG4B in Kaninchen hergestellte Antikörper	Sigma-Aldrich HPA045444 Anti-ATG16L2 antibody produced in rabbit
description fractionated antiserum, buffered aqueous solution	description purified immunoglobulin, buffered aqueous solution	description IgG fraction of antiserum, buffered aqueous solution	description Prestige Antibodies^® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
antibody form fractionated antiserum	antibody form purified immunoglobulin	antibody form IgG fraction of antiserum	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
mol wt antigen ~70 kDa (several isonform bands)	mol wt 68265 Da	mol wt antigen ~44 kDa	mol wt -
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous glycerol solution
shipped in dry ice	shipped in wet ice	shipped in dry ice	shipped in wet ice

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Lagerklasse

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c