This product is not tested for inducing an animal model of androgenic alopecia. Determination of suitability must be conducted experimentally.
A8380
5α-雄甾烷-17β-醇-3-酮
synthetic, ≥97.5%, Androgen hormone, powder
同義詞:
17β-羟基-5α-雄甾烷-3-酮, 4,5α-二氢睾酮, 雄甾烷醇酮, 雄诺龙
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經驗公式（希爾表示法）:
C19H30O2
CAS 編號:
分子量：:
290.44
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
EC Number:
208-307-3
MDL number:
Beilstein/REAXYS Number:
2056371
Assay:
≥97.5%
Form:
powder
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產品名稱
5α-雄甾烷-17β-醇-3-酮, ≥97.5%
biological source
synthetic
Quality Segment
sterility
non-sterile
assay
≥97.5%
form
powder
drug control
USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada
solubility
ethanol: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow
SMILES string
[H][C@@]12CC[C@@]3([H])[C@]4([H])CC[C@H](O)[C@@]4(C)CC[C@]3([H])[C@@]1(C)CCC(=O)C2
InChI
1S/C19H30O2/c1-18-9-7-13(20)11-12(18)3-4-14-15-5-6-17(21)19(15,2)10-8-16(14)18/h12,14-17,21H,3-11H2,1-2H3/t12-,14-,15-,16-,17-,18-,19-/m0/s1
InChI key
NVKAWKQGWWIWPM-ABEVXSGRSA-N
Gene Information
human ... AR(367), ESR1(2099), PGR(5241), SERPINA6(866), SHBG(6462)
mouse ... Esr1(13982)
rat ... Ar(24208), Esr1(24890), Nr3c1(24413), Nr3c2(25672), Pgr(25154)
Application
5α-雄甾烷-17β-醇-3-酮，也称为雄诺龙(androstanolone)或双氢睾酮，是一种合成代谢类固醇。 睾丸分泌的睾酮在目标组织中转变为双氢睾酮，介导睾酮的多种生物作用，包括胚胎发生和青春期的男性表型发育。
Biochem/physiol Actions
雄诺龙是一种合成代谢类固醇。睾丸分泌的睾酮在目标组织中转变为双氢睾酮，介导睾酮的多种生物作用。雄激素诱导胚胎发生和青春期的男性表型发育。
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本產品 | |||
|---|---|---|---|
| assay ≥97.5% | assay ≥99.0% (TLC) | assay ≥98% (TLC) | assay ≥97% (HPLC) |
| form powder | form powder | form powder | form powder |
| drug control USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada | drug control USDEA Schedule IIIN; regulated under CDSA - not available from Sigma-Aldrich Canada | drug control USDEA Schedule III; Home Office Schedule 4.2; regulated under CDSA - not available from Sigma-Aldrich Canada | drug control - |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| solubility ethanol: 50 mg/mL, clear to slightly hazy, colorless to very faintly yellow | solubility - | solubility methanol: 19.60-20.40 mg/mL, clear, colorless | solubility methanol: 50 mg/mL, clear, colorless |
| Gene Information human ... AR(367), ESR1(2099), PGR(5241), SERPINA6(866), SHBG(6462) | Gene Information - | Gene Information rat ... Ar(24208) | Gene Information - |
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 2 - Repr. 1A
存儲類別/等級
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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Is this product suitable for inducing an animal model of androgenic alopecia?
1 answer-
Helpful?
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Is it suitable to treat this in cell culture? I've already seen such recommendations.. However, the fact that it is not sterilized is a bit concerning. would it still be possible?
1 answer-
This product has not been tested for suitability in cell culture. While the powder is not sterile, prepared stock solutions may be filter sterilized. The material is soluble at 50 mg/mL in ethanol and may be further diluted using buffer or medium. The peer-reviewed papers listed on this page reference publications the have listed this product used in a number of applications successfully. There are several in vitro and in vivo applications cited. Please see the link below to review one example publication:
https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0099410Helpful?
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