A9232
AMI-1 sodium salt hydrate
≥98% (HPLC)
Synonym(s):
7,7′-Carbonylbis(azanediyl)bis(4-hydroxynaphthalene-2-sulfonic acid) sodium salt hydrate
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| Size/SKU | Availability | Price |
|---|---|---|
5 mg | Please contact Customer Service for Availability | $200.00 $170.00 |
25 mg | Please contact Customer Service for Availability | $700.00 $595.00 |
About This Item
Empirical Formula (Hill Notation):
C21H16N2O9S2 · xNa+ · yH2O
Molecular Weight:
504.49 (anhydrous free acid basis)
NACRES:
NA.77
UNSPSC Code:
12352200
Assay:
≥98% (HPLC)
Form:
powder
Storage condition:
desiccated, protect from light
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Please contact Customer Service for Availability
assay
≥98% (HPLC)
form
powder
storage condition
desiccated, protect from light
color
purple
solubility
H2O: >10 mg/mL
storage temp.
2-8°C
Biochem/physiol Actions
AMI-1 inhibits arginine, but not lysine, methyltransferase activity in vitro, while not interacting with S-adenosyl methionine (AdoMet), unlike most methyltransferase inhibitors which compete for the AdoMet binding site.
Protein arginine N-methyltransferases (PRMTs) are involved in post-translational modification implicated in protein trafficking, signal transduction, and transcriptional regulation. AMI-1 does not inhibit lysine methyltransferase activity and does not interact with S-adenosylmethionine (AdoMet), unlike most methyltransferase inhibitors which compete for the AdoMet binding site. AMI-1 can modulate nuclear receptor-regulated transcription from estrogen and androgen response elements; and is a HIV-1 reverse transcriptase inhibitor. AMI-1 is a potent antagonist of NADPH-oxidase-derived superoxide production, but acts as a direct antioxidant rather than indirectly through methyltransferase inhibition.
Features and Benefits
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This Item | |||
|---|---|---|---|
| form powder | form solid | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 200 |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. −20°C | storage temp. room temp |
| storage condition desiccated, protect from light | storage condition desiccated | storage condition desiccated | storage condition - |
| solubility H2O: >10 mg/mL | solubility DMSO: 10 mg/mL, clear (warmed) | solubility H2O: ≥10 mg/mL | solubility DMSO: 5 mg/mL, clear |
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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