Key Documents

View All Documentation

Anti-BACE 1, C-Terminus (485-501) antibody produced in rabbit

Name: Anti-BACE 1, C-Terminus (485-501) antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-β-Site APP Cleaving Enzyme

About This Item

UNSPSC Code:

12352203

NACRES:

NA.43

MDL number:

MFCD03454775

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, WB

Citations:

This product is discontinued. Contact Technical Servicefor assistance.

Properties

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 70 kDa

species reactivity

human

enhanced validation

recombinant expression
Learn more about Antibody Enhanced Validation

technique(s)

microarray: suitable, western blot: 1:1,000 using a whole cell extract from the human kidney HEK293 cell line stably transfected with human BACE-1

UniProt accession no.

P56817

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BACE1(23621)

Description

General description

BACE-1 (β-site APP cleaving enzyme, Asp2 or memapsin 2) is known as β-secretase. BACE-1 is highly expressed in neurons, the major site of Aβ generation. BACE-1 is localized within the Golgi and endosomal compartments, among the several intracellular sites where Aβ is thought to be produced. It constitutes the predominant β-secretase activity in human brain tissue.

Immunogen

synthetic peptide corresponding to the C-terminus of human BACE-1 (amino acids 485-501).

Application

Anti-BACE 1, C-Terminus (485-501) antibody produced in rabbit has been used in western blotting.

Biochem/physiol Actions

Overexpression of β-site APP cleaving enzyme (BACE-1) leads to increased β-secretase activity while displaying appropriate cleavage site specificity for amyloid precursor protein (APP).

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 1% bovine serum albumin and 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	B0681	SAB2100200	MAB5308
Sigma-Aldrich B0806 Anti-BACE 1, C-Terminus (485-501) antibody produced in rabbit	Sigma-Aldrich B0681 Anti-BACE 1, N-Terminus (46-62) antibody produced in rabbit	Sigma-Aldrich SAB2100200 Anti-BACE1 antibody produced in rabbit	Sigma-Aldrich MAB5308 Anti-BACE Antibody, CT, clone 61-3E7
biological source rabbit	biological source rabbit	biological source rabbit	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level 200	Quality Level 100	Quality Level 100
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form purified immunoglobulin
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form -
mol wt antigen 70 kDa	mol wt antigen 60-75 kDa	mol wt 51 kDa	mol wt -

Still not finding the right product?

Try our Product Selector Tool to narrow your options

Storage Class

12 - Non Combustible Liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

087M4882V

101K4871

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Docosahexaenoic acid reduces amyloid beta production via multiple pleiotropic mechanisms

Grimm MOW, et al.

Test, 286(16), 14028-14039 (2011)

Tocotrienol Affects Oxidative Stress, Cholesterol Homeostasis and the Amyloidogenic Pathway in Neuroblastoma Cells: Consequences for Alzheimer's Disease.

Marcus O W Grimm et al.

International journal of molecular sciences, 17(11) (2016-11-02)

One of the characteristics of Alzheimer´s disease (AD) is an increased amyloid load and an enhanced level of reactive oxidative species (ROS). Vitamin E has known beneficial neuroprotective effects, and previously, some studies suggested that vitamin E is associated with

The impact of capsaicinoids on APP processing in Alzheimer's disease in SH-SY5Y cells.