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BMP6, human

Name: BMP6, human
Brand: SIGMA
Price: 782 USD

>95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

Synonym(s):

Bone Morphogenetic Protein 6 human, BMP-6

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Pack Size	SKU	Availability	Price
20 μg		Check Cart for Availability	$782.00

About This Item

UNSPSC Code:

12352202

NACRES:

NA.32

MDL number:

MFCD02097809

Biological source:

human

Recombinant:

expressed in NSO cells

Assay:

>95% (SDS-PAGE)

Form:

lyophilized powder

Mol wt:

30–38 kDa

Impurities:

endotoxin, tested

$782.00

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Properties

Product Name

Bone Morphogenetic Protein 6 human, >95% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder, suitable for cell culture

biological source

human

Quality Level

100

recombinant

expressed in NSO cells

assay

>95% (SDS-PAGE)

form

lyophilized powder

potency

0.05-0.15 μg/mL ED₅₀

mol wt

30–38 kDa

packaging

pkg of 20 μg

storage condition

avoid repeated freeze/thaw cycles (Do not store in a frost-free freezer.)

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

P22004

storage temp.

−20°C

Gene Information

human ... BMP6(654)

Description

Biochem/physiol Actions

Cellular responses to BMP-6 are mediated by the formation of hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors. Mature human and murine BMP-6 demonstrates 96% homology.

Physical form

Lyophilized from 200 ul 0.2 μm filtered solution in 40% acetonitrile, 0.1% trifluoroacetic acid containing 50ug bovine serum albumin per 1 ug as a carrier protein.

Analysis Note

The biological activity is measured by its ability to induce alkaline phosphatase production by ATDC5 mouse chondrogenic cells.

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Show Differences

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This Item	B3795	H4916	H4791
Sigma-Aldrich B2805 Bone Morphogenetic Protein 6 human	Sigma-Aldrich B3795 Brain-derived neurotrophic factor human	Sigma-Aldrich H4916 Bone Morphogenetic Protein 4 human	Sigma-Aldrich H4791 Bone Morphogenetic Protein 2 human
biological source human	biological source human	biological source human	biological source human
recombinant expressed in NSO cells	recombinant expressed in E. coli	recombinant expressed in HEK 293 cells	recombinant expressed in HEK 293 cells
assay >95% (SDS-PAGE)	assay ≥95% (SDS-PAGE)	assay >95% (SDS-PAGE)	assay -
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 100
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Bone morphogenetic proteins and their receptors: potential functions in the brain.

Ebendal, T., et al

The Journal of Neuroscience, 51, 139-146 (1998)

Enhanced expression of BMP6 inhibits hepatic fibrosis in non-alcoholic fatty liver disease.

Stephanie Arndt et al.

Gut, 64(6), 973-981 (2014-07-12)

Bone morphogenetic protein 6 (BMP6) has been identified as crucial regulator of iron homeostasis. However, its further role in liver pathology including non-alcoholic fatty liver disease (NAFLD) and its advanced form non-alcoholic steatohepatitis (NASH) is elusive. The aim of this

Exome sequencing in HFE C282Y homozygous men with extreme phenotypes identifies a GNPAT variant associated with severe iron overload.

Christine E McLaren et al.

Hepatology (Baltimore, Md.), 62(2), 429-439 (2015-01-22)

To identify polymorphisms associated with variability of iron overload severity in HFE-associated hemochromatosis, we performed exome sequencing of DNA from 35 male HFE C282Y homozygotes with either markedly increased iron stores (n = 22; cases) or with normal or mildly increased iron

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Global Trade Item Number

SKU	GTIN
B2805-20UG	04061833427125

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