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Anti-Bax antibody produced in rabbit

Name: Anti-Bax antibody produced in rabbit
Brand: SIGMA

IgG fraction of antiserum, buffered aqueous solution

Synonym(s):

Anti-BCL2L4

About This Item

UNSPSC Code:

12352203

NACRES:

NA.46

MDL number:

MFCD00282585

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ARR, WB

Citations:

This product is discontinued. Contact Technical Servicefor assistance.

Properties

biological source

rabbit

Quality Level

200

conjugate

unconjugated

antibody form

IgG fraction of antiserum

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

antigen 23 kDa

species reactivity

human, rat, mouse

technique(s)

microarray: suitable, western blot: 1:2,000 using whole cell extract of MCF7 human breast adenocarcinoma cell line

UniProt accession no.

Q07812

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... BAX(581)
mouse ... Bax(12028)
rat ... Bax(24887)

Description

General description

Bax is a 21kD integral organelle membrane protein that belongs to the Bcl-2 family and is expressed mainly in the mitochondria. It exist in three cytosolic forms Bax β (24 kDa), Bax γ (5 kDa) and Bax δ (16 kDa) generated by alternative splicing.

Immunogen

synthetic peptide GGPTSSEQIMKTGALLLQGF-K corres- ponding to the N-terminal region of Bax of human origin (Bax α, amino acids 11-30 with C-terminally added lysine), conjugated to KLH as immunogen. This sequence is identical in human Bax β and highly conserved in rat and mouse Bax α (single amino acid substitution) and human Bax.

Application

Anti-BMPR2 (836-850) antibody produced in rabbit is suitable for western blotting at a concentration of 1:500-1:2,000.

Biochem/physiol Actions

BAX is a proapoptotic protein that forms homodimer to accelerate apoptotic death whereas its heterodimerization with Bcl-2 or Bcl-xL can block apoptosis^. BAX binds to the mitochondrial permeability transition pore complex (PTPC), and when expressed in cells, it induces mitochondrial dysfunction and the release of cytochrome C, leading to activation of caspases and triggers apoptosis. Loss-of-function mutation in the BAX gene results in Hematopoietic malignancies.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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This Item	SAB3500343	SAB4502549	SAB5700056
$Anti-Bax antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich B3428 Anti-Bax antibody produced in rabbit	$Anti-Bax antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich SAB3500343 Anti-Bax antibody produced in rabbit	Sigma-Aldrich SAB4502549 Anti-BAX antibody produced in rabbit	Sigma-Aldrich SAB5700056 Anti-BAX antibody produced in rabbit
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
antibody form IgG fraction of antiserum	antibody form IgG fraction of antiserum	antibody form affinity isolated antibody	antibody form affinity isolated antibody
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
Quality Level 200	Quality Level -	Quality Level 100	Quality Level 100
shipped in dry ice	shipped in dry ice	shipped in wet ice	shipped in wet ice
form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution	form buffered aqueous solution

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

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L-Arginine enhances cell proliferation and reduces apoptosis in human endometrial RL95-2 cells.

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Reproductive biology and endocrinology : RB&E, 11, 15-15 (2013-02-28)

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Paclitaxel resistance development is associated with biphasic changes in reactive oxygen species, mitochondrial membrane potential and autophagy with elevated energy production capacity in lung cancer cells: A chronological study.

Satabdi Datta et al.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 39(2), 1010428317694314-1010428317694314 (2017-02-28)

Paclitaxel (Tx) is one of the first-line chemotherapeutic drugs used against lung cancer, but acquired resistance to this drug is a major challenge against successful chemotherapy. In this work, we have focused on the chronological changes of various cellular parameters

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.

P H Schlesinger et al.

Proceedings of the National Academy of Sciences of the United States of America, 94(21), 11357-11362 (1997-10-23)

The BCL-2 family of proteins is composed of both pro- and antiapoptotic regulators, although its most critical biochemical functions remain uncertain. The structural similarity between the BCL-XL monomer and several ion-pore-forming bacterial toxins has prompted electrophysiologic studies. Both BAX and

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Global Trade Item Number

SKU	GTIN
B3428-.1ML	04061838161017

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