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C1104

Monoclonal Anti-Caspase 7 antibody produced in rat

Name: Monoclonal Anti-Caspase 7 antibody produced in rat
Brand: SIGMA

clone 11E4, purified immunoglobulin, buffered aqueous solution

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UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD01633625

Conjugate:

unconjugated

Clone:

11E4, monoclonal

Application:

ARR, IP, WB

Citations:

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Propiedades

biological source

rat

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

11E4, monoclonal

form

buffered aqueous solution

mol wt

antigen (full length) 35 kDa, antigen (subunit) 20 kDa

species reactivity

human

technique(s)

immunoprecipitation (IP): suitable, microarray: suitable, western blot: 2-4 μg/mL using a whole extract of cultured human acute T cell leukemia Jurkat cells

isotype

IgG2a

UniProt accession no.

P55210

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... CASP7(840)

Descripción

General description

Caspase-7 is a apoptosis-related cysteine peptidase, commonly known as CASP7. It is a human protein encoded by the CASP7 gene. CASP7 is a member of the caspase (cysteine aspartate protease) family of proteins and is an executioner protein of apoptosis.

Immunogen

recombinant p20 subunit of human caspase-7.

Application

Monoclonal Anti-Caspase 7 antibody produced in rat is suitable for the following applications:

Immunoprecipitation
Microarray
Western blotting at a concentration of 2-4μg/mL using a whole extract of cultured human acute T cell leukemia Jurkat cells.

Biochem/physiol Actions

Caspase-3 and -7 plays a central role in the execution-phase of cell apoptosis. The gene for caspase 7 (also known as Mch3, CMH-1 and ICELAP3) encodes a “short” prodomain protein product of 35 kDa that belongs to the Ced3/ICE family of cysteine proteases. Caspase 7 undergoes acleavage upon activation by caspase-3, -9 and -10, and granzyme B, leading to p20 and p12 subunits. It is an important intracellular effector of granzyme B-mediated apoptosis and cytotoxic Tlymphocyte- induced cell killing in vivo. Monoclonal antibodies reacting specifically with caspase 7 are useful tools for the study of protease networks involved in development and regulation and governing the life and death of cells and tissues.

Preparation Note

The antibody is purified from culture supernatant of hybridoma cells grown in a bioreactor.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Este artículo	C4106	C9598	C5737
Sigma-Aldrich C1104 Monoclonal Anti-Caspase 7 antibody produced in rat	Sigma-Aldrich C4106 Anti-Caspase 8 antibody, Mouse monoclonal	$Anti-Caspase 3 antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution$ Sigma-Aldrich C9598 Anti-Caspase 3 antibody produced in rabbit	Sigma-Aldrich C5737 Monoclonal Anti-Caspase 3 antibody produced in mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
clone 11E4, monoclonal	clone CAS8, monoclonal	clone polyclonal	clone 84803.111, monoclonal
antibody form purified immunoglobulin	antibody form purified immunoglobulin	antibody form IgG fraction of antiserum	antibody form purified immunoglobulin
biological source rat	biological source mouse	biological source rabbit	biological source mouse
species reactivity human	species reactivity human	species reactivity human	species reactivity human
Gene Information human ... CASP7(840)	Gene Information human ... CASP8(841)	Gene Information human ... CASP3(836)	Gene Information human ... CASP3(836)

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