Key Documents

(±)-CGP-12177A

Name: (±)-CGP-12177A
Brand: SIGMA

≥98% (HPLC), solid

Synonym(s):

(±)-CGP-12177 hydrochloride, 4-[3-[(1,1-Dimethylethyl)amino]-2-hydroxypropoxy]-1, 3-dihydro-2H-benzimidazol-2-one hydrochloride

About This Item

Empirical Formula (Hill Notation):

C₁₄H₂₁N₃O₃ · HCl

CAS Number:

64208-32-8

Molecular Weight:

315.80

NACRES:

NA.77

PubChem Substance ID:

24277768

UNSPSC Code:

12352200

MDL number:

MFCD00069230

Assay:

≥98% (HPLC)

Form:

solid

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Properties

Quality Segment

100

assay

≥98% (HPLC)

form

solid

color

white

solubility

DMSO: >10 mg/mL

SMILES string

Cl.CC(C)(C)NCC(O)COc1cccc2NC(=O)Nc12

InChI

1S/C14H21N3O3.ClH/c1-14(2,3)15-7-9(18)8-20-11-6-4-5-10-12(11)17-13(19)16-10;/h4-6,9,15,18H,7-8H2,1-3H3,(H2,16,17,19);1H

InChI key

YQVFCYCTITZLSX-UHFFFAOYSA-N

Gene Information

human ... ADRB1(153), ADRB2(154), ADRB3(155)

Description

Application

(±)-CGP-12177A has been used as a β-Adrenergic receptor agonist:

to evaluate the dissociation constant (Kd) by frontal affinity chromatography[1]
to study its cardiostimulant effects on rat ventricular cardiomyocytes[2]
to study its binding affinity in α_1D-adrenoceptors expressed in rat BHK-21 cells[3]

Biochem/physiol Actions

β-adrenoceptor nonconventional partial agonist.

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Show Differences

1 of 1

This Item	D9190	SML0362	B4313
Sigma-Aldrich C125 (±)-CGP-12177A	Sigma-Aldrich D9190 DCEBIO	Sigma-Aldrich SML0362 NPS2143 hydrochloride	Sigma-Aldrich B4313 (E/Z)-BCI hydrochloride
description ≥98% (HPLC), solid	description ≥98% (HPLC), solid	description ≥98% (HPLC)	description ≥98% (HPLC)
form solid	form solid	form powder	form powder
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
solubility DMSO: >10 mg/mL	solubility DMSO: >10 mg/mL	solubility DMSO: >10 mg/mL	solubility DMSO: 10 mg/mL, clear
color white	color white to off-white	color white to beige	color white to beige
Gene Information human ... ADRB1(153), ADRB2(154), ADRB3(155)	Gene Information human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR5B(645694), HTR6(3362), HTR7(3363)	Gene Information -	Gene Information -

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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