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C8679
Chicago Sky Blue 6B
powder
Synonym(s):
Direct Blue 1, Pontamine sky blue
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About This Item
Empirical Formula (Hill Notation):
C34H24N6Na4O16S4
CAS Number:
Molecular Weight:
992.80
PubChem Substance ID:
UNSPSC Code:
12171500
Colour Index Number:
24410
NACRES:
NA.47
EC Number:
220-026-8
MDL number:
Skip To
InChI key
BPHHNXJPFPEJOF-GPTZEZBUSA-J
InChI
1S/C34H28N6O16S4.4Na/c1-55-23-11-15(3-7-19(23)37-39-21-9-5-17-25(57(43,44)45)13-27(59(49,50)51)31(35)29(17)33(21)41)16-4-8-20(24(12-16)56-2)38-40-22-10-6-18-26(58(46,47)48)14-28(60(52,53)54)32(36)30(18)34(22)42;;;;/h3-14,41-42H,35-36H2,1-2H3,(H,43,44,45)(H,46,47,48)(H,49,50,51)(H,52,53,54);;;;/q;4*+1/p-4/b39-37+,40-38+;;;;
SMILES string
[Na+].[Na+].[Na+].[Na+].COc1cc(ccc1\N=N\c2ccc3c(cc(c(N)c3c2O)S([O-])(=O)=O)S([O-])(=O)=O)-c4ccc(\N=N\c5ccc6c(cc(c(N)c6c5O)S([O-])(=O)=O)S([O-])(=O)=O)c(OC)c4
form
powder
composition
Dye content, ~80%
color
blue
solubility
H2O: 10 mg/mL
application(s)
diagnostic assay manufacturing
hematology
histology
storage temp.
room temp
Quality Level
1 of 4
This Item | A5268 | A3157 | M5528 |
|---|---|---|---|
| color blue | color blue | color dark blue | color - |
| form powder | form powder | form powder | form powder |
| application(s) diagnostic assay manufacturing | application(s) diagnostic assay manufacturing | application(s) diagnostic assay manufacturing | application(s) diagnostic assay manufacturing |
| solubility H2O: 10 mg/mL | solubility H2O: 1 mg/mL | solubility water: 1 mg/mL, blue | solubility H2O: 1 mg/mL, blue |
| storage temp. room temp | storage temp. room temp | storage temp. room temp | storage temp. room temp |
| composition Dye content, ~80% | composition Dye content, 45-65% | composition Dye content, ≥50% | composition - |
Application
Biochem/physiol Actions
Chicago Sky Blue 6B is a large organic acid, structurally related to glutamate, that is a potent and efficient competitive inhibitor of vesicular glutamate uptake.[4]
signalword
Danger
hcodes
Hazard Classifications
Carc. 1B
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
flash_point_f
Not applicable
flash_point_c
Not applicable
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Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation.
Li S, et al.
Journal of Neurophysiology, 98, 3525-3525 (2007)
Detection of aromatase in human endometrial tissue cultured in three-dimensional fibrin matrix in vitro.
Jafar A, et al.
International journal of reproductive biomedicine (Yazd, Iran), 7, 105-109 (2009)
T Cowen et al.
Histochemistry, 82(3), 205-208 (1985-01-01)
The stain pontamine sky blue (PSB) has been shown to reduce background autofluorescence in catecholamine fluorescence and immunofluorescence histochemical preparations. Using PSB as a counterstain on whole-mount stretch preparations of human mesenteric blood vessels, a medium dense noradrenergic nerve plexus
S Roseth et al.
Journal of neurochemistry, 65(1), 96-103 (1995-07-01)
In this study we have described a series of new and potent inhibitors of the vesicular uptake of glutamate. The two most efficient inhibitors were the dyes Evans blue and Chicago Skye Blue 6B, which are structurally related to glutamate
Responses to tactile stimulation in deep cerebellar nucleus neurons result from recurrent activation in multiple pathways.
Rowland NC and Jaeger D
Journal of Neurophysiology, 99, 704-704 (2008)
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Hi, I need to know information to Chicago Sky Blue - is available declaration of conformity for this stain? New requirtments regulation of IVDR.
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