D0443
Sustine 470
Synonym(s):
Dextranase Plus L, 1,6-α-D-Glucan 6-glucanohydrolase
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 50 mL | Please contact Customer Service for Availability | $170.00 | |
| 250 mL | Please contact Customer Service for Availability | $335.00 |
About This Item
UNSPSC Code:
12352204
NACRES:
NA.54
EC Number:
232-803-9
MDL number:
$170.00
Please contact Customer Service for Availability
General description
A product of Novozymes Corp.
Dextranase is generated by many microorganisms, including bacteria, filamentous fungi, and yeast.
Application
Dextranase from Chaetomium erraticum has been used:
- in microcarrier dissolution to produce multicellular 3D spheroids for drug discovery[1]
- in in vitro digestion of extracellular polysaccharide (EPS) from the bacterial isolates[2]
- in a study to investigate the immobilization of dextranase
- to investigate the optimization of process conditions for enzymatic modification of alternan
Biochem/physiol Actions
Dextranase is an endodextranase that hydrolyzes α-(1,6)-glycosidic linkages in dextran. It has many industrial and clinical applications such as food processing, sugar modification, and medicine preparation. Dextranase is widely used to produce alternated sugar beet and isomaltooligosaccharides (IMOs), a prebiotic functional food.[3] The low molecular weight dextran obtained from dextranase serves as a synthetic blood volume expander. Dextranase can be coupled to antibodies for the detection of tumor cells.[3] It prevents the occurrence of dental plaques by depolymerizing microbial dextran deposits in teeth. Hence, it is used in dental care products.
Preparation Note
A fungal dextranase produced by submerged fermentation of Chaetomium erraticum.
Analysis Note
Stable in the pH range of 3-7 and at temperatures up to approx. 70 °C. For most applications, the preferred conditions are pH 5-6 and a temperature of 50-60 °C.
Other Notes
View more information on enzymes for complex carbohydrate analysis at www.sigma-aldrich.com/enzymeexplorer
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| form solution | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C | storage temp. 2-8°C |
| Quality Level 300 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Storage Class
10 - Combustible liquids
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Articles
Uncover more about glycosaminoglycans and proteoglycans including the structure of glycosaminoglycans (GAGs), the different types of GAGs, and their functions.
F Abeille et al.
Lab on a chip, 14(18), 3510-3518 (2014-07-12)
Microfluidic bioreactors are expected to impact cell therapy and biopharmaceutical production due to their ability to control cellular microenvironments. This work presents a novel approach for continuous cell culture in a microfluidic system. Microcarriers (i.e., microbeads) are used as growth
Co-immobilization of dextransucrase and dextranase in epoxy-agarose-tailoring oligosaccharides synthesis
da Silva R, et al.
Process Biochemistry (Oxford, United Kingdom), 78, 71-81 (2019)
Laura Montani et al.
Methods in molecular biology (Clifton, N.J.), 827, 305-317 (2011-12-07)
In contrast to typical Rho GTPases the regulation of atypical Rho GTPases, such as the members of the RhoBTB subfamily, rarely depends on GEFs and/or GAPs. Instead, they are regulated at the level of their expression, by post-translational modifications, by
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D0443-50ML | 04061833557686 |
| D0443-250ML | 04061838172525 |