The solubility of this produst is tested in water at 50 mg/mL The solubility in saline has not been tested, however rates are expected to be similar. The solution stability has not been determined. Other sources state that solutions are stable for up to 1 month when stored in aliquots at -20°C.
D1159
Dexamethasone 21-phosphate disodium salt
≥98%, Glucocorticoid , powder
Sign In to View Organizational & Contract Pricing.
Select a Size
Change View
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 100 mg | Please contact Customer Service for Availability | $102.00 | |
| 500 mg | Please contact Customer Service for Availability | $342.00 | |
| 1 g | Please contact Customer Service for Availability | $566.00 $481.10 | |
| 5 g | Please contact Customer Service for Availability | $1,590.00 $1,351.50 |
About This Item
Empirical Formula (Hill Notation):
C22H28FNa2O8P
CAS Number:
Molecular Weight:
516.40
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
51422340
EC Number:
219-243-0
MDL number:
Beilstein/REAXYS Number:
6473066
Product Name
Dexamethasone 21-phosphate disodium salt, ≥98%
Quality Level
assay
≥98%
form
powder
impurities
≤1% ethanol
color
white to off-white
storage temp.
2-8°C
SMILES string
[Na+].[Na+].[H][C@@]12CCC3=CC(=O)C=C[C@]3(C)[C@@]1(F)[C@@H](O)C[C@@]4(C)[C@@]2([H])C[C@@H](C)[C@]4(O)C(=O)COP([O-])([O-])=O
InChI
1S/C22H30FO8P.2Na/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30;;/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30);;/q;2*+1/p-2/t12-,15+,16+,17+,19+,20+,21+,22+;;/m1../s1
InChI key
PLCQGRYPOISRTQ-FCJDYXGNSA-L
Gene Information
human ... NR3C1(2908)
Application
Dexamethasone 21-phosphate disodium salt has been used:
- as a positive control to study its effects on ocular shedding of herpes simplex virus type 1 (HSV-1) in the induced reactivation (IR) and spontaneous shedding (SS) rabbit models[1]
- as a receptor analog to study its effects on glucocorticoid receptor activation in suprachiasmatic nuclei (SCN)-lesioned mice[2]
- to study its protective effects against cisplatin-induced ototoxicity in the inner ear of guinea pigs[3]
Biochem/physiol Actions
Dexamethasone 21-phosphate (Dex 21-P) is a pro-drug[4] that can undergo dephosphorylation to form dexamethasone with the help of intra-erythrocyte enzymes.[5] It exhibits therapeutic effects against cystic fibrosis[4] and postoperative cataract. Dex 21-P disodium salt is a synthetic adrenal corticosteroid and possesses anti-inflammatory activity.
1 of 1
This Item | |||
|---|---|---|---|
| assay ≥98% | assay ≥99% | assay ≥97% | assay ≥98% (HPLC) |
| form powder | form powder | form powder | form powder |
| storage temp. 2-8°C | storage temp. 2-8°C | storage temp. room temp | storage temp. 2-8°C |
| Quality Level 100 | Quality Level 100 | Quality Level 100 | Quality Level 200 |
| color white to off-white | color - | color - | color off-white |
| impurities ≤1% ethanol | impurities - | impurities - | impurities - |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Repr. 2
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Choose from one of the most recent versions:
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Effect of operational conditions on the supercritical carbon dioxide impregnation of anti-inflammatory and antibiotic drugs in rigid commercial intraocular lenses
Bouledjouidja A, et al.
Journal of Supercritical Fluids, 130, 63-75 (2017)
Donal T Skelly et al.
Molecular psychiatry, 24(10), 1533-1548 (2018-06-08)
Systemic inflammation can impair cognition with relevance to dementia, delirium and post-operative cognitive dysfunction. Episodes of delirium also contribute to rates of long-term cognitive decline, implying that these acute events induce injury. Whether systemic inflammation-induced acute dysfunction and acute brain
Marieke Veurink et al.
Pharmaceutical research, 30(4), 1176-1187 (2013-02-16)
To investigate the mechanism behind the aggregation breaking properties of dexamethasone phosphate and related corticosteroids on the IgG1 antibody bevacizumab (Avastin®). An in silico 3D dimer model is developed to identify the bevacizumab-bevacizumab interface, and different corticosteroids are docked onto
Global Trade Item Number
| SKU | GTIN |
|---|---|
| D1159-500MG | 04061833289303 |
| D1159-100MG | 04061833558874 |
| D1159-1G | 04061833558881 |
| D1159-5G | 04061833558898 |
-
We planned to dissolve it into saline and use to to inject as prenatal stressor to Sprague-Dawley rats via IP way. What is the solubility? I want to dissolve 100µg and 200µg into 10ml of saline. After dissolving what is the shelf life of that solution?
1 answer-
Helpful?
-