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E8651

Anti-E2F3 antibody ,Mouse monoclonal

Name: Anti-E2F3 antibody ,Mouse monoclonal
Brand: SIGMA
Price: 554 EUR

clone PG30, purified from hybridoma cell culture

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Ihnen/SKU	Verfügbarkeit	Preis
0.2 mL	Warenkorb auf Verfügbarkeit prüfen	€ 554,00

Über diesen Artikel

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD00283127

Conjugate:

unconjugated

Clone:

PG30, monoclonal

Application:

ARR, IP, WB

Citations:

€ 554,00

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Technischer Dienst

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Eigenschaften

biological source

mouse

Quality Segment

200

conjugate

unconjugated

antibody form

purified from hybridoma cell culture

antibody product type

primary antibodies

clone

PG30, monoclonal

form

buffered aqueous solution

mol wt

antigen 57 kDa

species reactivity

human

concentration

~2 mg/mL

technique(s)

immunoprecipitation (IP): suitable using denatured E2F3, microarray: suitable, western blot: 4-8 μg/mL using transfected 293T cells expressing E2F3

isotype

IgG2a

UniProt accession no.

O00716

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... E2F3(1871)

Beschreibung

General description

Monoclonal Anti-E2F3 (mouse IgG2a isotype) is derived from the PG30 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from BALB/c mice immunized with a recombinant human E2F Transcription Factor 3 (E2F3) protein. Transcription factor E2F3 is a DNA-binding protein of ~57 kDa encoded by the E2F3 gene in humans. It belongs to E2F transcription factor family of proteins that bind to the sequence TTTCGCGC.

Immunogen

recombinant human E2F3.

Application

Monoclonal Anti-E2F3 antibody produced in mouse has been used for the following applications:

immunoprecipitation using denatured E2F3
western blotting at a concentration of 4-8μg/mL using transfected 293T cells expressing E2F3
electrophoretic mobility shift assay (EMSA).

Biochem/physiol Actions

Transcription factor E2F3 is involved in the regulation of cell cycle. E2F3 helps in the regulation of the expression of a number of genes that are important in cell proliferation. It is a oncogene with strong proliferative potential and is involved in many processes. E2F3 plays an important role in the development of several types of cancer. Overexpression of E2F3 may be associated with hepatocellular carcinoma (HCC). It plays an important role in controlling cell cycle progression and proliferation. E2F3 is frequently expressed in pediatric Wilms′ tumors and may be associated with the same.

Physical form

Solution in phosphate buffered saline, pH 7.4, containing 1% BSA and 15 mM sodium azide.

Preparation Note

Purified from culture supernatant of hybridoma cells grown in a bioreactor.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Dieser Artikel	WH0001871M1	AV38089	E8655
Sigma-Aldrich E8651 Anti-E2F3 antibody ,Mouse monoclonal	Sigma-Aldrich WH0001871M1 Monoclonal Anti-E2F3 antibody produced in mouse	Sigma-Aldrich AV38089 Anti-E2F3 antibody produced in rabbit	Sigma-Aldrich E8655 Anti-E6AP antibody, Mouse monoclonal
description clone PG30, purified from hybridoma cell culture	description clone 5F7, purified immunoglobulin, buffered aqueous solution	description affinity isolated antibody	description clone E6AP-330, purified from hybridoma cell culture
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
species reactivity human	species reactivity human	species reactivity mouse, human, dog, guinea pig, rat, horse, bovine	species reactivity human, mouse, rat, monkey
Gene Information human ... E2F3(1871)	Gene Information human ... E2F3(1871)	Gene Information human ... E2F3(1871)	Gene Information human ... E2F6(1876) mouse ... E2f6(50496) rat ... E2f6(313978)
antibody form purified from hybridoma cell culture	antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form purified from hybridoma cell culture
clone PG30, monoclonal	clone 5F7, monoclonal	clone polyclonal	clone E6AP-330, monoclonal
biological source mouse	biological source mouse	biological source rabbit	biological source mouse

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Lagerklasse

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c