This understanding is correct, however, the stabilizer content is approximately 70%. The lot-specific Certificate of Analysis will provide the exact stabilizer content, which can then be used to calculate the amount of β-Estradiol 3-Sulfate.
https://www.sigmaaldrich.com/product/sigma/e9505#product-documentation
E9505
β-Estradiol 3-sulfate sodium salt
≥93%
Synonyme(s) :
1,3,5(10)-Estratriene-3,17β-diol 3-sulfate, 3,17β-Dihydroxy-1,3,5(10)-estratriene 3-sulfate
pour consulter les tarifs organisationnels et contractuels.
A propos de cet article
Formule linéaire :
C18H23O5SNa
Numéro CAS:
Poids moléculaire :
374.43
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
51111800
MDL number:
Assay:
≥93%
Form:
powder
sterility
non-sterile
Quality Segment
assay
≥93%
form
powder
contains
~70% N-methyl-D-glucamine as stabilizer
solubility
methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow
shipped in
ambient
storage temp.
room temp
SMILES string
[Na].[H][C@]12CC[C@]3(C)[C@@H](O)CC[C@@]3([H])[C@]1([H])CCc4cc(OS(O)(=O)=O)ccc24
InChI
1S/C18H24O5S.Na.H/c1-18-9-8-14-13-5-3-12(23-24(20,21)22)10-11(13)2-4-15(14)16(18)6-7-17(18)19;;/h3,5,10,14-17,19H,2,4,6-9H2,1H3,(H,20,21,22);;/t14-,15-,16+,17+,18+;;/m1../s1
InChI key
PYPVMTJYMKHIST-LBARCDFESA-N
General description
β-Estradiol is secreted by developing ovaries and is predominant during premenopause in women.
Application
β-Estradiol 3-sulfate sodium salt has been used to measure the estradiol level from culture supernatant in ultra-performance liquid chromatography-tandem mass spectrometry.
Biochem/physiol Actions
β-Estradiol is a steroid hormone involved in a number of organ functions. It is significantly associated with brain functions including neuroprotection, neurogenesis and synaptic plasticity. β-Estradiol maintains bone homeostasis, hence it is preferred for osteoporosis therapy. 17-β-Estradiol is the most active estrogen generated in our body. During postmenopausal, 17-β-estradiol inhibits oxidative modification in low density lipoprotein. This indicates that estrogen replacement therapy might be useful in treating cardiovascular disease.
Packaging
Package size based on steroid content
1 of 1
Cet article | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥93% | assay ≥98% (TLC) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| storage temp. room temp | storage temp. −20°C | storage temp. −20°C | storage temp. −20°C |
| solubility methanol: 9.80-10.20 mg/mL, clear, colorless to faintly yellow | solubility water: 50 mg/mL, clear, colorless | solubility 0.1 M NaOH: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow | solubility water: 10 mg/mL, clear to slightly hazy |
| shipped in ambient | shipped in ambient | shipped in ambient | shipped in ambient |
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Carc. 2
Classe de stockage
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type P3 (EN 143) respirator cartridges
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The description of the product says that it contains 70 % N-methyl-D-glucamine as a stabilizer. Does this mean that 1.0 mg of the powder contains 0.3 mg of β-Estradiol 3-sulfate and that I need to weigh in 3.33 mg of the powder to get 1 mg of substance?
1 réponse-
Utile ?
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