E9902
Ephrin-A1/Fc Chimera from mouse
>90% (SDS-PAGE), recombinant, expressed in NSO cells, lyophilized powder
Sinonimo/i:
B61, EFL-1, LERK-1
Autenticati per visualizzare i prezzi organizzativi e contrattuali.
Informazioni su questo articolo
biological source
mouse
Quality Level
recombinant
expressed in NSO cells
assay
>90% (SDS-PAGE)
form
lyophilized powder
potency
0.16-10 ng/mL
mol wt
monomer calculated mol wt 46.8 kDa, 50-55 kDa by SDS-PAGE (reducing)
packaging
pkg of 200 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
UniProt accession no.
storage temp.
−20°C
Gene Information
mouse ... Efna1(13636)
Biochem/physiol Actions
EphA1 (ephrin receptor A1) plays an essential role in development, and is involved in the guidance of axonal and cell migration in nervous system.[1] Disruption of ephrin signaling might be involved in the tumorigenesis of clear cell renal cell carcinoma, and absence of EphA1 has a favorable prognosis in the same.[2] It might also be involved in the tumorigenesis and progression of prostate cancer, and might have potential as a marker for prognosis, as well as a therapeutic target.[3] Studies show that it reduces the risk of Alzheimer′s disease, by hindering pathological changes in brain areas such as, hippocampus, lateral occipitotemporal and inferior temporal gyri.[4] In esophageal squamous cells, it acts as differentiation marker. Its expression is elevated in esophageal squamous cell carcinoma, and this relates to advanced stage and metastasis to lymph node.[5]
Member of ephrin ligand family that binds Eph receptor tyrosine kinases (EphA1, EphA2, EphA3, EphA4, EphA5, EphA6, EphA7 and EphB1). Involved in pattern formation and morphogenesis. Ephrin-A1 can be detected on fetal osteoblasts, odotoblasts, chondrocytes, and squamous epithelium. Ephrin-A1 is expressed during embryonic vasculogenesis and during tumor-induced angiogenesis.
Physical form
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Analysis Note
The biological activity is measured by its ability to bind recombinant mouse EphA2/Fc in ELISA.
Other Notes
Extracellular domain of mouse ephrin-A1 (amino acids 1-182) fused to the C-terminal 6X histidine-tagged Fc region of human IgG.
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Questo articolo | |||
|---|---|---|---|
| assay >90% (SDS-PAGE) | assay >90% (SDS-PAGE) | assay >90% (SDS-PAGE) | assay >90% (SDS-PAGE) |
| biological source mouse | biological source mouse | biological source human | biological source human |
| recombinant expressed in NSO cells | recombinant expressed in NSO cells | recombinant expressed in NSO cells | recombinant expressed in NSO cells |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 200 |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| impurities endotoxin, tested | impurities endotoxin, tested | impurities endotoxin, tested | impurities endotoxin, tested |
Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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Contenuto correlato
Datasheet
Augustin DuSablon et al.
PloS one, 12(12), e0189307-e0189307 (2017-12-14)
EphrinA1, a membrane-bound receptor tyrosine kinase ligand expressed in healthy cardiomyocytes, is lost in injured cells following myocardial infarction. Previously, we have reported that a single intramyocardial injection of chimeric ephrinA1-Fc at the time of ischemia reduced injury in the
Matthieu Chavent et al.
Biochemistry, 53(42), 6641-6652 (2014-10-07)
EphA1 is a receptor tyrosine kinase (RTK) that plays a key role in developmental processes, including guidance of the migration of axons and cells in the nervous system. EphA1, in common with other RTKs, contains an N-terminal extracellular domain, a
Hui-Fu Wang et al.
Journal of Alzheimer's disease : JAD, 44(1), 115-123 (2014-09-04)
Ephrin type-A receptor 1 (EPHA1) (11771145) was documented to be one of the most strongly associated locus with Alzheimer's disease (AD) in a recent meta-analysis of five genome wide association studies. However, its contribution to the pathogenesis of AD remains
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| E9902-200UG | 04061833609262 |