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G013

R(+)-Baclofen hydrochloride

solid

Synonym(s):

Arbaclofen hydrochloride, R(+)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid hydrochloride, STX209

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25 mg

Available to ship TODAYfromMILWAUKEE

$242.00
100 mg

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$757.00
$643.45
500 mg

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$2,820.00

About This Item

Empirical Formula (Hill Notation):
C10H12ClNO2 · HCl
CAS Number:
63701-55-3
Molecular Weight:
250.12
NACRES:
NA.32
PubChem Substance ID:
24895006
UNSPSC Code:
12352200
MDL number:
MFCD00078579

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form

solid

Quality Segment

100

optical activity

[α]28/D +3.8°, c = 0.9 in methanol(lit.)

storage condition

desiccated

color

white

solubility

DMSO: >20 mg/mL, H2O: 26 mg/mL (Solutions may be stored for several weeks at 4 °C.)

SMILES string

Cl[H].NC[C@H](CC(O)=O)c1ccc(Cl)cc1

InChI

1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1

InChI key

WMNUVYYLMCMHLU-QRPNPIFTSA-N

Gene Information

human ... GABBR1(2550)
mouse ... GABBR1(54393)
rat ... GABBR1(81657)

Application

R(+)-Baclofen hydrochloride has been used as a GABAB receptor agonist to study its effects on M43068-induced antinociception in rat models. It has also been used as a GABAB receptor agonist to study its effects on amphetamine-induced behavior and neurochemical responses in rat striatum.

Biochem/physiol Actions

Baclofen is a derivative of γ-aminobutyric acid (GABA) and acts as a 4-aminobutanoic acid receptor (GABAB) agonist. It interacts stereospecifically with the GABA receptor and exhibits antispastic effects.Baclofen shows therapeutic effects against paroxysmal pain of trigeminal neuralgia and spinal spasticity. R(+)-Baclofen is a more active enantiomer.

Other Notes

Same enantiomer as R(−)-baclofen free base.

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This Item
P118B5399B0200000
R(+)-Baclofen hydrochloride solid

Sigma-Aldrich

G013

R(+)-Baclofen hydrochloride

Phaclofen solid

Sigma-Aldrich

P118

Phaclofen

(±)-Baclofen ≥98% (HPLC), solid

Sigma-Aldrich

B5399

(±)-Baclofen

Baclofen European Pharmacopoeia (EP) Reference Standard

B0200000

Baclofen

description

solid

description

solid

description

≥98% (HPLC), solid

description

European Pharmacopoeia (EP) Reference Standard

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

-

form

solid

form

solid

form

solid

form

-

Gene Information

human ... GABBR1(2550)
mouse ... GABBR1(54393)
rat ... GABBR1(81657)

Gene Information

human ... GABBR1(2550), GABBR2(9568)

Gene Information

human ... GABBR1(2550), GABBR2(9568)
rat ... Gabbr1(81657), Gabra2(29706)

Gene Information

human ... GABBR1(2550), GABBR2(9568)

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

color

white

color

white

color

white to very faintly yellow

color

-

optical activity

[α]28/D +3.8°, c = 0.9 in methanol(lit.)

optical activity

-

optical activity

-

optical activity

-

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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