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G013

R(+)-Baclofen hydrochloride

solid

Synonym(s):

Arbaclofen hydrochloride, R(+)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid hydrochloride, STX209

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Size/SKUAvailabilityPrice
25 mg
Please contact Customer Service for Availability
$298.00
100 mg
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$896.00
$761.60
500 mg
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$3,570.00

About This Item

Empirical Formula (Hill Notation):
C10H12ClNO2 · HCl
CAS Number:
Molecular Weight:
250.12
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:

$298.00


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form

solid

Quality Segment

optical activity

[α]28/D +3.8°, c = 0.9 in methanol(lit.)

storage condition

desiccated

color

white

solubility

DMSO: >20 mg/mL, H2O: 26 mg/mL (Solutions may be stored for several weeks at 4 °C.)

SMILES string

Cl[H].NC[C@H](CC(O)=O)c1ccc(Cl)cc1

InChI

1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1

InChI key

WMNUVYYLMCMHLU-QRPNPIFTSA-N

Gene Information

human ... GABBR1(2550)
mouse ... GABBR1(54393)
rat ... GABBR1(81657)

Application

R(+)-Baclofen hydrochloride has been used as a GABAB receptor agonist to study its effects on M43068-induced antinociception in rat models. It has also been used as a GABAB receptor agonist to study its effects on amphetamine-induced behavior and neurochemical responses in rat striatum.

Biochem/physiol Actions

Baclofen is a derivative of γ-aminobutyric acid (GABA) and acts as a 4-aminobutanoic acid receptor (GABAB) agonist. It interacts stereospecifically with the GABA receptor and exhibits antispastic effects.Baclofen shows therapeutic effects against paroxysmal pain of trigeminal neuralgia and spinal spasticity. R(+)-Baclofen is a more active enantiomer.

Other Notes

Same enantiomer as R(−)-baclofen free base.

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This Item
B5399B02000001048200
description

solid

description

≥98% (HPLC), solid

description

European Pharmacopoeia (EP) Reference Standard

description

United States Pharmacopeia (USP) Reference Standard

Quality Level

100

Quality Level

100

Quality Level

-

Quality Level

-

form

solid

form

solid

form

-

form

-

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

Gene Information

human ... GABBR1(2550)
mouse ... GABBR1(54393)
rat ... GABBR1(81657)

Gene Information

human ... GABBR1(2550), GABBR2(9568)
rat ... Gabbr1(81657), Gabra2(29706)

Gene Information

human ... GABBR1(2550), GABBR2(9568)

Gene Information

human ... GABBR1(2550), GABBR2(9568)

solubility

H2O: 26 mg/mL (Solutions may be stored for several weeks at 4 °C.), DMSO: >20 mg/mL

solubility

1 M HCl: 50 mg/mL

solubility

-

solubility

-

optical activity

[α]28/D +3.8°, c = 0.9 in methanol(lit.)

optical activity

-

optical activity

-

optical activity

-


Storage Class

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

PPE (personal protective equipment)

Eyeshields, Gloves, type N95 (US)



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