Key Documents

Monoclonal Anti-LSD1 (AOF2) antibody produced in mouse

Name: Monoclonal Anti-LSD1 (AOF2) antibody produced in mouse
Brand: SIGMA
Price: 55577.7 INR
Availability: InStock

~2 mg/mL, clone LSD1-12, purified immunoglobulin, buffered aqueous solution

Synonym(s):

Anti-Amine oxidase, flavin-containing, 2, Anti-BHC110, Anti-BRAF-HDAC complex protein 110, Anti-KIAA0601 protein, Anti-Lysine-specific demethylase 1

Select a Size

Change View

Size/SKU	Availability	Price
200 μL	Estimated to ship on10 November 2026fromBangalore Non-Bonded Warehouse	₹55,577.70

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD09039194

Conjugate:

unconjugated

Clone:

LSD1-12, monoclonal

Application:

Citations:

₹55,577.70

Estimated to ship on10 November 2026Details

New, lower price on this item!

Request a Custom Order

Technical Service

Need help? Our team of experienced scientists is here for you.

Let Us Assist

Properties

biological source

mouse

Quality Segment

300

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

LSD1-12, monoclonal

form

buffered aqueous solution

mol wt

antigen ~110 kDa

species reactivity

mouse, human

concentration

~2 mg/mL

technique(s)

western blot: 0.5-1 μg/mL using MCF7 total cell extract

isotype

IgG1

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... AOF2(23028)
mouse ... Aof2(99982)

Description

General description

Monoclonal Anti-LSD1 (AOF2) (mouse IgG1 isotype) is derived from the hybridoma LSD1-12 produced by the fusion of mouse myeloma cells (NS1) and splenocytes from BALB/c mice. Lysine specific demethylase 1 (LSD1) also known as amine oxidase flavin-containing domain 2 (AOF2) () is a lysine-specific demethylase. It is a nuclear protein containing a SWIRM (Swi3p, Rsc8p and Moira) domain, a flavin adenine dinucleotide (FAD)-binding motif and an amine oxidase domain. The LSD1 gene is mapped to human chromosome 1p36.12. LSD1 is referred to by additional names including KDM1A protein, BHC110(BRAF-HDAC complex protein 110) and nuclear polyamine oxidase (NPAO)().

Immunogen

synthetic peptide corresponding to amino acids 832-847 of human LSD1/BHC110. This sequence is identical in bovine, rat, mouse, and frog.

Application

Monoclonal Anti-LSD1 (AOF2) antibody produced in mouse has been used:

immunofluorescence
immunoblotting
immunoprecipitation
immunocytochemistry

Biochem/physiol Actions

Lysine Specific Demethylase 1 (LSD1) is a component of several histone deacetylase complexes that function through modifying chromatin structure to repress transcription.LSD1 action can signal either activation or repression of transcription. Demethylation of histone H3 Lys4 by LSD1 leads to transcriptional repression of target genes, while demethylation of histone H3 at Lys9 leads to depression of androgen receptor target genes. The activity of LSD1 (AOF2) is regulated by its associated factors namely, corepressor to the REST (RE1 silencing transcription factor/neural restrictive silencing factor)(CoREST). This, in turn, promotes demethylation by enhancing the association of LSD1 with the nucleosomes and also protects LSD1 from proteasomal degradation. LSD1 is a component of nucleosome remodeling and deacetylase (NuRD). It regulates neuronal development and favors neural stem cell proliferation. It highly expressed in acute myeloid leukemia and many solid tumors.

Monoclonal Anti-LSD1 (AOF2) recognizes human and mouse LSD1.

Physical form

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.

Preparation Note

For continuous use, store at 2-8 °C for up to one month. For extended storage, freeze in working aliquots. Repeated freezing and thawing, or storage in “frost-free” freezers, is not recommended. If slight turbidity occurs upon prolonged storage, clarify the solution by centrifugation before use. Working dilutions should be discarded if not used within 12 hours.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item	L4418	R2404	WH0023028M4
Sigma-Aldrich L7293 Monoclonal Anti-LSD1 (AOF2) antibody produced in mouse	Sigma-Aldrich L4418 Anti-LSD1 (AOF2) (C-terminal) antibody produced in rabbit	Sigma-Aldrich R2404 Anti-Raf-1/c-Raf antibody, Mouse monoclonal	Sigma-Aldrich WH0023028M4 Monoclonal Anti-AOF2 antibody produced in mouse
description ~2 mg/mL, clone LSD1-12, purified immunoglobulin, buffered aqueous solution	description ~1 mg/mL, affinity isolated antibody, buffered aqueous solution	description clone RNP1, purified from hybridoma cell culture	description clone 2E7, purified immunoglobulin, buffered aqueous solution
biological source mouse	biological source rabbit	biological source mouse	biological source mouse
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
clone LSD1-12, monoclonal	clone polyclonal	clone RNP1, monoclonal	clone 2E7, monoclonal
Gene Information human ... AOF2(23028) mouse ... Aof2(99982)	Gene Information human ... AOF2(23028) mouse ... Aof2(99982)	Gene Information human ... RAF1(5894) mouse ... Raf1(110157) rat ... Raf1(24703)	Gene Information human ... AOF2(23028)
antibody form purified immunoglobulin	antibody form affinity isolated antibody	antibody form purified immunoglobulin	antibody form purified immunoglobulin
species reactivity mouse, human	species reactivity human, mouse (predicted), rat (predicted)	species reactivity rat, mouse, human	species reactivity human

Still not finding the right product?

Try our Product Selector Tool to narrow your options

Storage Class

10 - Combustible liquids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documents section.

If you need assistance, please contact Customer Support

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.