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Anti-ICAD antibody produced in rabbit

Name: Anti-ICAD antibody produced in rabbit
Brand: SIGMA

affinity isolated antibody, buffered aqueous solution

Synonym(s):

Anti-DFF45, Anti-DNA fragmentation factor, α-subunit

About This Item

UNSPSC Code:

12352203

NACRES:

NA.41

MDL number:

MFCD02096208

Conjugate:

unconjugated

Clone:

polyclonal

Application:

ELISA (i), IF, IHC, WB

Citations:

This product is discontinued. Contact Technical Servicefor assistance.

Properties

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

form

buffered aqueous solution

mol wt

predicted mol wt 45 kDa

species reactivity

mouse

technique(s)

immunofluorescence: suitable, immunohistochemistry: suitable, indirect ELISA: suitable, western blot: suitable

UniProt accession no.

O54786

shipped in

dry ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

mouse ... Dffa(13347)

Description

General description

The gene DNA fragmentation factor subunit α (DFFA) is mapped to human chromosome 1p36.2. The encoded protein localizes to the chromatin fraction. It exist in association with DFF40, thereby forming a heterodimer. DFFA is popularly called as DFF45 (DNA fragmentation factor 45).

Immunogen

a peptide corresponding to amino acids 312-331 of mouse ICAD.

Biochem/physiol Actions

DNA fragmentation factor subunit α (DFFA) is a component of DNA fragmentation factor (DFF). It is mainly associated with apoptosis and genomic stability. Caspase-3-mediated cleavage of DFFA releases DFF40 (DNA fragmentation factor 40) which degrades chromosomal DNA. During menstruation, the apoptosis of endometrium cells is associated with DFFA. Its expression decreases after menopause. Silencing of DFFA increases doxorubicin effects in breast cancer cells.

Physical form

Solution in phosphate buffered saline containing 0.02% sodium azide

Other Notes

The action of this antibody can be blocked using blocking peptide SBP2003.

Compare Similar Items

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Show Differences

1 of 1

This Item	HPA069341	HPA057266	PRS2007
Sigma-Aldrich PRS2003 Anti-ICAD antibody produced in rabbit	Sigma-Aldrich HPA069341 Anti-CAD antibody produced in rabbit	Sigma-Aldrich HPA057266 Anti-CAD antibody produced in rabbit	Sigma-Aldrich PRS2007 Anti-CAD antibody produced in rabbit
antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody	antibody form affinity isolated antibody
biological source rabbit	biological source rabbit	biological source rabbit	biological source rabbit
conjugate unconjugated	conjugate unconjugated	conjugate unconjugated	conjugate unconjugated
storage temp. −20°C	storage temp. −20°C	storage temp. −20°C	storage temp. −20°C
UniProt accession no. O54786	UniProt accession no. P27708	UniProt accession no. P27708	UniProt accession no. O54788
form buffered aqueous solution	form buffered aqueous glycerol solution	form buffered aqueous glycerol solution	form -

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Storage Class

10 - Combustible liquids

wgk

WGK 2

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

20030303

2003-0303

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Histone H1 subtype preferences of DFF40 and possible nuclear localization of DFF40/45 in normal and trichostatin A-treated NB4 leukemic cells.

Ninios YP, et al.

Apoptosis, 15, 128-138 (2010)

DNA fragmentation factor 45 (DFF45) gene at 1p36.2 is homozygously deleted and encodes variant transcripts in neuroblastoma cell line.

Yang HW, et al.

Neoplasia, 3, 165-169 (2001)

DFF45 expression in human endometrium is associated with menstrual cycle phases and decreases after menopause.

Banas T, et al.

Gynecologic and Obstetric Investigation, 73, 177-182 (2012)

View All Related Papers

Global Trade Item Number

SKU	GTIN
SBP2003-0.05MG	04061832165271
PRS2003-100UG	04061831489132

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